Universität zu Köln

Moesges, Ralph, Passali, Desiderio and Di Gioacchino, Mario (2021). Worldwide surveys on anaphylaxis to sublingual immunotherapy with house dust mite tablets are urgently needed. Clin. Transl. Allergy, 11 (1). HOBOKEN: WILEY. ISSN 2045-7022

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Abstract

In the 1980s, a global number of 72 fatalities were reported in the UK and the USA following the application of subcutaneous immunotherapy (SCIT). This resulted in a significant limitation of SCIT use and in the search of other routes of administration, among which sublingual immunotherapy (SLIT) showed the best balance between efficacy and safety. Data from controlled studies suggest that tablets-related anaphylaxis is an uncommon event. However, in the Eudravigilance (European database of suspected adverse drug reactions from Europe) we found reports of life-threatening events or severe local reactions under SLIT increasing over the last few years. Therefore, all efforts to minimize the related risk have to be strongly encouraged.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Passali, Desiderio UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Gioacchino, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586607
DOI:	10.1002/clt2.12012
Journal or Publication Title:	Clin. Transl. Allergy
Volume:	11
Number:	1
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2045-7022
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SAFETY Multiple languages Allergy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58660