Froelich, Matthias Frank, Schnitzer, Moritz Ludwig, Holzgreve, Adrien, Gassert, Felix Gerhard, Gresser, Eva ORCID: 0000-0002-2780-2025, Overhoff, Daniel, Schwarze, Vincent, Fabritius, Matthias Philipp, Noerenberg, Dominik, von Muenchhausen, Niklas, Hokamp, Nils Grosse, Auernhammer, Christoph J., Ilhan, Harun, Todica, Andrei and Ruebenthaler, Johannes (2021). Cost-Effectiveness Analysis of Ga-68 DOTA-TATE PET/CT, In-111-Pentetreotide SPECT/CT and CT for Diagnostic Workup of Neuroendocrine Tumors. Diagnostics, 11 (2). BASEL: MDPI. ISSN 2075-4418

Full text not available from this repository.

Abstract

Neuroendocrine tumors (NETs) are relatively rare neoplasms arising from the hormone-producing neuroendocrine system that can occur in various organs such as pancreas, small bowel, stomach and lung. As the majority of these tumors express somatostatin receptors (SSR) on their cell membrane, utilization of SSR analogs in nuclear medicine is a promising, but relatively costly approach for detection and localization. The aim of this study was to analyze the cost-effectiveness of Ga-68-DOTA-TATE PET/CT (Gallium-68 DOTA-TATE Positron emission tomography/computed tomography) compared to In-111-pentetreotide SPECT/CT (Indium-111 pentetreotide Single Photon emission computed tomography/computed tomography) and to CT (computed tomography) alone in detection of NETs. A decision model on the basis of Markov simulations evaluated lifetime costs and quality-adjusted life years (QALYs) related to either a CT, SPECT/CT or PET/CT. Model input parameters were obtained from publicized research projects. The analysis is grounded on the US healthcare system. Deterministic sensitivity analysis of diagnostic parameters and probabilistic sensitivity analysis predicated on a Monte Carlo simulation with 30,000 reiterations was executed. The willingness-to-pay (WTP) was determined to be $100,000/QALY. In the base-case investigation, PET/CT ended up with total costs of $88,003.07 with an efficacy of 4.179, whereas CT ended up with total costs of $88,894.71 with an efficacy of 4.165. SPECT/CT ended up with total costs of $89,973.34 with an efficacy of 4.158. Therefore, the strategies CT and SPECT/CT were dominated by PET/CT in the base-case scenario. In the sensitivity analyses, PET/CT remained a cost-effective strategy. This result was due to reduced therapy costs of timely detection. The additional costs of Ga-68-DOTA-TATE PET/CT when compared to CT alone are justified in the light of potential savings in therapy costs and better outcomes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Froelich, Matthias FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzer, Moritz LudwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holzgreve, AdrienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gassert, Felix GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gresser, EvaUNSPECIFIEDorcid.org/0000-0002-2780-2025UNSPECIFIED
Overhoff, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarze, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabritius, Matthias PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noerenberg, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Muenchhausen, NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hokamp, Nils GrosseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auernhammer, Christoph J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilhan, HarunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todica, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruebenthaler, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-586684
DOI: 10.3390/diagnostics11020334
Journal or Publication Title: Diagnostics
Volume: 11
Number: 2
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2075-4418
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58668

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item