Universität zu Köln

Hou, Xiaoyi ORCID: 0000-0001-5657-4984, Guo, Yongwei ORCID: 0000-0001-9195-0770, Liu, Jinhua, Li, Senmao, Fan, Wanlin, Lin, Ming ORCID: 0000-0001-6467-4643, Rokohl, Alexander C. and Heindl, Ludwig M. (2021). A Systematic Review of the Clinical Manifestations and Diagnostic Methods for Macular Coloboma. Curr. Eye Res., 46 (7). S. 913 - 919. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1460-2202

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Abstract

Objectives: To present the clinical features of and diagnostic methods used for macular coloboma (MC), and to analyze the factors associated with best-corrected visual acuity (BCVA) in patients with MC. Methods: A systematic review using the MEDLINE (PubMed), EMBASE, LILACS, and Cochrane databases was performed. The factors associated with BCVA were analyzed. Results: A total of 21 patients (mean age at diagnosis, 18.1 +/- 14.6 years) with 36 eyes affected by MC (5 unilateral, 16 bilateral) were included in the study. All 21 patients (100%) had undergone a good-quality fundus examination. The size of the MC lesions ranged from 1.0 x 1.2 to 4.0 x 4.0 disc diameters (DD). Twenty-seven (73%) eyes had pigmented MC, seven (19%) had non-pigmented MC, and one (3%) had an unspecific type. The diagnosis was confirmed using spectral-domain optical coherence tomography (SD-OCT) in 16 (43.2%) eyes. A positive correlation was found between BCVA and the type of MC (beta = 0.876, p = .006) and abnormal eye movement (beta = 0.087, p = .018), and a negative correlation was found between BCVA and a contributory medical history of ventricular septal defect (beta = -0.327, p = .001). Conclusions: Pigmented MC was the most common type and had the highest possibility of causing impaired vision in the affected eyes. Additionally, joint examinations should be applied for diagnostic confirmation of MC. Furthermore, fundoscopy, electroretinogram, electrooculography, fundus fluorescein angiography, and SD-OCT are all critical for differential diagnosis of MC-like lesions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hou, Xiaoyi UNSPECIFIED orcid.org/0000-0001-5657-4984 UNSPECIFIED Guo, Yongwei UNSPECIFIED orcid.org/0000-0001-9195-0770 UNSPECIFIED Liu, Jinhua UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Senmao UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Wanlin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Ming UNSPECIFIED orcid.org/0000-0001-6467-4643 UNSPECIFIED Rokohl, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586872
DOI:	10.1080/02713683.2020.1853779
Journal or Publication Title:	Curr. Eye Res.
Volume:	46
Number:	7
Page Range:	S. 913 - 919
Date:	2021
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1460-2202
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58687