Universität zu Köln

Lichtenstein, Thorsten, Sprenger, Alina, Weiss, Kilian ORCID: 0000-0003-4295-4585, Hokamp, Nils Grosse, Maintz, David, Schlamann, Marc, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Lehmann, Helmar C. and Henning, Tobias D. (2021). MRI DTI and PDFF as Biomarkers for Lower Motor Neuron Degeneration in ALS. Front. Neurosci., 15. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-453X

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Abstract

Objective To evaluate the utility of nerve magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and muscle MRI multi-echo Dixon for assessing lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS). Methods In this prospective observational cohort study, 14 patients with ALS and 13 healthy controls underwent a multiparametric MRI protocol, including DTI of the sciatic nerve and assessment of muscle proton density fat fraction of the biceps femoris and the quadriceps femoris muscles by a multi-echo Dixon sequence. Results In ALS patients, mean fractional anisotropy values of the sciatic nerve were significantly lower than those of healthy controls. The quadriceps femoris, but not the biceps femoris muscle, showed significantly higher intramuscular fat fractions in ALS. Interpretation Our study provides evidence that multiparametric MRI protocols might help estimate structural nerve damage and neurogenic muscle changes in ALS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lichtenstein, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprenger, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED orcid.org/0000-0003-4295-4585 UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henning, Tobias D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587363
DOI:	10.3389/fnins.2021.682126
Journal or Publication Title:	Front. Neurosci.
Volume:	15
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-453X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIFFUSION TENSOR MRI; NERVE; MUSCLE; INVOLVEMENT; DAMAGE Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58736