Kiljan, Martha, Weil, Sabrina, Vasquez-Torres, Andres, Hettich, Meike, Mayer, Marimel, Ibruli, Olta, Reinscheid, Matthias, Hesselmann, Isabelle, Cai, Jiali, Niu, Li-na, Sahbaz, Yagmur, Baues, Christian, Baus, Wolfgang W., Kamp, Florian, Marnitz, Simone, Herter-Sprie, Grit S. and Herter, Jan M. (2021). CyberKnife radiation therapy as a platform for translational mouse studies. Int. J. Radiat. Biol., 97 (9). S. 1261 - 1270. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1362-3095

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Abstract

Purpose Radiation therapy (RT) is a common nonsurgical treatment in the management of patients with cancer. While genetically engineered mouse models (GEMM) recapitulate human disease, conventional linear particle accelerator systems are not suited for state-of-the-art, imageguided targeted RT (IGRT) of these murine tumors. We employed the CyberKnife (CK; Accuray) platform for IGRT of GEMM-derived non-small cell lung cancer (NSCLC) lesions. Material and methods GEMM-derived Kras(LSL-G12D/+)/Trp53(fl/fl) -driven NSCLC flank tumors were irradiated using the CK RT platform. We applied IGRT of 2, 4, 6, and 8 Gy using field sizes of 5-12.5 mm to average gross tumor volumes (GTV) of 0.9 cm3 using Xsight Spine Tracking (Accuray). Results We found that 0 mm planning target volume (PTV) margin is sufficient for IGRT of murine tumors using the CK. We observed that higher RT doses (6-8 Gy) decreased absolute cell numbers of tumor infiltrating leukocytes (TIL) by approximately half compared to low doses (2-4 Gy) within 1 h, but even with low dose RT (2 Gy) TIL were found to be reduced after 8-24 h. Conclusion We here demonstrate that the CK RT system allows for targeted IGRT of murine tumors with high precision and constitutes a novel promising platform for translational mouse RT studies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kiljan, MarthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weil, SabrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasquez-Torres, AndresUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hettich, MeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, MarimelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ibruli, OltaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinscheid, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hesselmann, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cai, JialiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niu, Li-naUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sahbaz, YagmurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baues, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baus, Wolfgang W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamp, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marnitz, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herter-Sprie, Grit S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herter, Jan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-587385
DOI: 10.1080/09553002.2021.1934749
Journal or Publication Title: Int. J. Radiat. Biol.
Volume: 97
Number: 9
Page Range: S. 1261 - 1270
Date: 2021
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1362-3095
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUTROPHIL RECRUITMENT; RADIOTHERAPY; CANCER; IRRADIATION; IMMUNOTHERAPY; RADIOSURGERY; TECHNOLOGY; CHALLENGESMultiple languages
Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58738

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