Universität zu Köln

Gehlsen, Uta, Stary, Daniela, Maass, Martina, Riesner, Katarina ORCID: 0000-0001-5745-8184, Musial, Gwen, Stern, Michael E., Penack, Olaf and Steven, Philipp ORCID: 0000-0001-6892-3619 (2021). Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis. Int. J. Mol. Sci., 22 (12). BASEL: MDPI. ISSN 1422-0067

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Abstract

Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive sight-threatening consequences. The therapeutic window of opportunity is narrow, and current treatment options are limited and often insufficient. To achieve new insights into the pathogenesis and to develop new therapeutic approaches, clinically relevant models of oGVHD are desirable. In this study, the ocular phenotype was described in a murine, chemotherapy-based, minor-mismatch GVHD model mimicking early-onset chronic oGVHD, with corneal epitheliopathy, inflammation of the lacrimal glands, and blepharitis. Additionally, corneal lymphangiogenesis was observed as part of oGVHD pathogenesis for the first time, thus opening up the investigation of lymphangiogenesis as a potential therapeutic and diagnostic tool.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gehlsen, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Stary, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Maass, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Riesner, Katarina UNSPECIFIED orcid.org/0000-0001-5745-8184 UNSPECIFIED Musial, Gwen UNSPECIFIED UNSPECIFIED UNSPECIFIED Stern, Michael E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Penack, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED orcid.org/0000-0001-6892-3619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587524
DOI:	10.3390/ijms22126191
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	12
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE GVHD; T-CELLS; LYMPHANGIOGENESIS; SURFACE; INHIBITION; CRITERIA; VIVO Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58752