Universität zu Köln

Calderaro, Mara, Baethge, Christopher, Bermpohl, Felix ORCID: 0000-0002-3260-6328, Gutwinski, Stefan, Schouler-Ocak, Meryam and Henssler, Jonathan ORCID: 0000-0001-8123-5853 (2022). Offspring's risk for suicidal behaviour in relation to parental death by suicide: systematic review and meta-analysis and a model for familial transmission of suicide. Br. J. Psychiatry, 220 (3). S. 121 - 130. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1472-1465

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Abstract

Background Exposure to parental suicide has been associated with increased risk for suicide and suicide attempts, although the strength of this association is unclear as evidence remains inconsistent. Aims To quantify this risk using meta-analysis and identify potential effect modifiers. Method A systematic search in PubMed, PsycInfo and Embase databases to 2020 netted 3614 articles. Inclusion criteria were: observation of history of parental death by suicide, comparison with non-exposed populations and definition of suicide and suicide attempt according to standardised criteria. We focused on population-based studies. The primary outcome was the pooled relative risk (RR) for incidence of suicide attempt and suicide in offspring of a parent who died by suicide compared with offspring of two living parents. Additionally, we compared the RR for attempted and completed suicide after parental suicide with the RR for attempted and completed suicide after parental death by other causes. Results Twenty studies met our inclusion criteria. Offspring exposed to parental suicide were more likely to die by suicide (RR = 2.97, 95% CI 2.50-3.53) and attempt suicide (RR = 1.76, 95% CI 1.58-1.96) than offspring of two living parents. Furthermore, their risk of dying by or attempting suicide was significantly higher compared with offspring bereaved by other causes of death. Conclusions The experience of losing a parent to suicide is a strong and independent risk factor for suicidal behaviour in offspring. Our findings highlight the need for prevention strategies, outreach programmes and support interventions that target suicide-related outcomes in the exposed population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Calderaro, Mara UNSPECIFIED UNSPECIFIED UNSPECIFIED Baethge, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Bermpohl, Felix UNSPECIFIED orcid.org/0000-0002-3260-6328 UNSPECIFIED Gutwinski, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schouler-Ocak, Meryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Henssler, Jonathan UNSPECIFIED orcid.org/0000-0001-8123-5853 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587556
DOI:	10.1192/bjp.2021.158
Journal or Publication Title:	Br. J. Psychiatry
Volume:	220
Number:	3
Page Range:	S. 121 - 130
Date:	2022
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1472-1465
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPLETED SUICIDE; PSYCHIATRIC-DISORDER; COMPLICATED GRIEF; BEREAVEMENT; GENETICS; CHILDREN; HISTORY; PSYCHOPATHOLOGY; HOSPITALIZATION; ADOLESCENTS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58755