Joisten, Niklas ORCID: 0000-0002-9947-8746, Rademacher, Annette, Warnke, Clemens, Proschinger, Sebastian, Schenk, Alexander, Walzik, David, Knoop, Andre, Thevis, Mario, Steffen, Falk, Bittner, Stefan, Gonzenbach, Roman, Kool, Jan, Bloch, Wilhelm, Bansi, Jens and Zimmer, Philipp (2021). Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis. Neurol.-Neuroimmunol. Neuroinflammation, 8 (3). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2332-7812

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Abstract

Objective To examine acute (single-bout) and training effects of high-intensity interval training (HIIT) vs standard exercise therapy (moderate continuous training [MCT]) on plasma neurofilament light chain (pNfL) and kynurenine (KYN) pathway of tryptophan degradation metabolites in persons with multiple sclerosis (pwMS). Methods Sixty-nine pwMS (Expanded Disability Status Scale score 3.0-6.0) were randomly assigned to a HIIT or an MCT group. Changes in pNfL and KYN pathway metabolites measured in blood plasma were assessed before, after, and 3 hours after the first training session as well as after the 3-week training intervention. Results Acute exercise reduced pNfL and increased the KYN pathway flux toward the neuroprotective kynurenic acid (KA). Changes in pNfL correlated positively with changes in KA and negatively with the quinolinic acid-to-KA ratio. HIIT consistently led to greater effects than MCT. Following the 3-week training intervention, the KYN pathway was activated in HIIT compared with MCT. Conclusion Future studies and clinical assessments of pNfL should consider acute exercise as confounding factor for measurement reliability. Moreover, exercise-induced KYN pathway rerouting might mediate neuroprotection, potentially underlying the benefits in rehabilitation for pwMS. Classification of Evidence This study provides Class II evidence that acute HIIT diminishes pNfL and increases KA levels, and 3 weeks of HIIT activate the KYN pathway in pwMS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Joisten, NiklasUNSPECIFIEDorcid.org/0000-0002-9947-8746UNSPECIFIED
Rademacher, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Proschinger, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schenk, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walzik, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoop, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffen, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bittner, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzenbach, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kool, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bloch, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bansi, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmer, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-587951
DOI: 10.1212/NXI.0000000000000982
Journal or Publication Title: Neurol.-Neuroimmunol. Neuroinflammation
Volume: 8
Number: 3
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 2332-7812
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
METABOLISM; ENDURANCE; SERUM; MSMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58795

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