Universität zu Köln

Michno, Viktoria, Malter, Wolfram, Paepke, Stefan, Thill, Marc, Kelling, Katharina, Meire, Anette, Tofall, Sabrina, Nolte, Elke, Christ, Hildegard and Eichler, Christian (2022). Impact of demographic and perioperative risk factors on complication rates in skin-sparing/nipple-sparing mastectomy with implant-based reconstruction using titanized polypropylene mesh (TiLOOP (R) Bra). Surg. Oncol.-Oxf., 40. OXFORD: ELSEVIER SCI LTD. ISSN 1879-3320

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Abstract

Background: Skin/nipple-sparing mastectomies (SSM/NSSM) have been reported to have acceptable complication rates and good aesthetic outcomes with high patient satisfaction. However, in this relatively young and rapidly expanding field of reconstructive plastic surgery, differences in perioperative management are noted between breast centers. Prospective studies of complication rates using a titanized polypropylene mesh (TiLOOP (R) Bra) are currently lacking. Methods: A prospective subgroup analysis was performed based on the data set of the prospective, single-arm, multicenter observational study (PRO-BRA). Early complication rates after skin/nipple-sparing mastectomy with implant-based immediate or secondary reconstruction using a titanized polypropylene mesh (TiLOOP (R) Bra) subpectorally were investigated in relation to demographic factors, as well as intra-and postoperative management. The subgroup consists of 258 patients. Complications were categorised into necrosis, infection, postoperative bleeding or hematoma, seroma, wound healing delays and R1-situations. Results: Early complication rates of SSM/NSSM using titanium-based meshes are comparable to complication-rates using ADM's. Logistic regression shows significantly higher risk for wound healing delays, necrosis and seroma with increasing BMI, abladat- and implant-weight (OR 1,17 -1,66, p-value < 0,001). Smokers have significantly higher necrosis rates (20.7%) compared to non-smokers (5.5%) (p-value = 0.002). Discharge with drainage results in a trend toward higher rates of wound healing complications. Conclusion: The use of TiLOOP (R) Bra meshes was shown to have acceptable complication rates. Complication rates depend on certain demographic and intraoperative risk factors and should be considered in indications and information of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Michno, Viktoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Paepke, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Thill, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Kelling, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Meire, Anette UNSPECIFIED UNSPECIFIED UNSPECIFIED Tofall, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Nolte, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588389
DOI:	10.1016/j.suronc.2021.101675
Journal or Publication Title:	Surg. Oncol.-Oxf.
Volume:	40
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-3320
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMEDIATE BREAST RECONSTRUCTION; PATIENT-REPORTED OUTCOMES; TISSUE EXPANDER; PREDICTORS; SATISFACTION; RADIATION; FLAP Multiple languages Oncology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58838