Universität zu Köln

Bilstein, Andreas ORCID: 0000-0002-1849-2520, Heinrich, Anja, Rybachuk, Anna ORCID: 0000-0001-5306-5412 and Moesges, Ralph (2021). Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface. Biomed Res. Int., 2021. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

The ocular surface is facing various unspecific stress factors resulting in irritation and inflammation of the epithelia, causing discomfort to the patients. Ectoine is a bacteria-derived extremolyte with the ability to protect proteins and biological membranes from damage caused by extreme environmental conditions like heat, UV-light, high osmolarity, or dryness. Evidence from preclinical and clinical studies attest its effectiveness in treating several epithelium-associated inflammatory diseases, including the eye surface. In this review, we analysed 16 recent clinical trials investigating ectoine eye drops in patients with allergic conjunctivitis or with other unspecific ocular inflammations caused by e.g. ophthalmic surgery. Findings from these studies were reviewed in context with other published work on ectoine. In summary, patients with irritations and unspecific inflammations of the ocular surface have been treated successfully with ectoine-containing eye drops. In these patients, significant improvement was observed in ocular symptoms of allergic rhinoconjunctivitis, postoperative secondary dry eye syndrome, or ocular reepithelisation after surgery. Using ectoine as an add-on therapy to antihistamines, in allergy patients accelerated symptom relief by days, and its use as an add-on to antibiotics resulted in faster wound closure. Ectoine is a natural substance with an excellent tolerability and safety profile thus representing a helpful alternative for patients with inflammatory irritation of the ocular surface, who wish to avoid local reactions and side effects associated with pharmacological therapies or wish to increase the efficacy of standard treatment regimen.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bilstein, Andreas UNSPECIFIED orcid.org/0000-0002-1849-2520 UNSPECIFIED Heinrich, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Rybachuk, Anna UNSPECIFIED orcid.org/0000-0001-5306-5412 UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588865
DOI:	10.1155/2021/8885032
Journal or Publication Title:	Biomed Res. Int.
Volume:	2021
Date:	2021
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOPHYSICAL INVESTIGATIONS; PART Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58886