Universität zu Köln

Weller, Anna, Bischof, Gerard N., Schlueter, Philipp, Richter, Nils, Dronse, Julian, Onur, Oezguer, Neumaier, Bernd, Kukolja, Juraj, Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Fink, Gereon, Kunoth, Angela, Shao, Yaping, van Eimeren, Thilo ORCID: 0000-0002-6951-2325 and Drzezga, Alexander ORCID: 0000-0001-6018-716X (2021). Finding New Communities: A Principle of Neuronal Network Reorganization in Alzheimer's Disease. Brain Connect., 11 (3). S. 225 - 239. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 2158-0022

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Abstract

Background: Graph-theoretical analyses have been previously used to investigate changes in the functional connectome in patients with Alzheimer's disease (AD). However, these analyses generally assume static organizational principles, thereby neglecting a fundamental reconfiguration of functional connections in the face of neurodegeneration. Methods: Here, we focus on differences in the community structure of the functional connectome in young and old individuals and patients with AD. Patients with AD, moreover, underwent molecular imaging positron emission tomography by using [18F]AV1451 to measure tau burden, a major hallmark of AD. Results: Although the overall organizational principles of the community structure of the human functional connectome were preserved even in advanced healthy aging, they were considerably changed in AD. We discovered that the communities in AD are re-organized, with nodes changing their allegiance to communities, thus resulting in an overall less efficient re-organized community structure. We further discovered that nodes with a tendency to leave the communities displayed a relatively higher tau pathology burden. Discussion: Together, this study suggests that local tau pathology in AD is associated to fundamental changes in basic organizational principles of the human connectome. Our results shed new light on previous findings obtained by using the graph theory in AD and imply a general principle of the brain in response to neurodegeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weller, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlueter, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Dronse, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Fink, Gereon UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunoth, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Shao, Yaping UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588998
DOI:	10.1089/brain.2020.0889
Journal or Publication Title:	Brain Connect.
Volume:	11
Number:	3
Page Range:	S. 225 - 239
Date:	2021
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	2158-0022
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TAU; CONNECTIVITY; REGISTRATION; MODULARITY; PATHOLOGY; BURDEN Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58899