Universität zu Köln

Schueller, Canan Beate, Wagner, Ben Jonathan, Schueller, Thomas, Baldermann, Juan Carlos, Huys, Daniel ORCID: 0000-0002-9124-4128, Koerner, Julia Kerner Auch, Niessen, Eva ORCID: 0000-0002-2801-0986, Muenchau, Alexander, Brandt, Valerie, Peters, Jan and Kuhn, Jens (2021). Temporal discounting in adolescents and adults with Tourette syndrome. PLoS One, 16 (6). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Tourette syndrome is a neurodevelopmental disorder associated with hyperactivity in dopaminergic networks. Dopaminergic hyperactivity in the basal ganglia has previously been linked to increased sensitivity to positive reinforcement and increases in choice impulsivity. In this study, we examine whether this extends to changes in temporal discounting, where impulsivity is operationalized as an increased preference for smaller-but-sooner over larger-but-later rewards. We assessed intertemporal choice in two studies including nineteen adolescents (age: mean[sd] = 14.21[+/- 2.37], 13 male subjects) and twenty-five adult patients (age: mean[sd] = 29.88 [+/- 9.03]; 19 male subjects) with Tourette syndrome and healthy age- and education matched controls. Computational modeling using exponential and hyperbolic discounting models via hierarchical Bayesian parameter estimation revealed reduced temporal discounting in adolescent patients, and no evidence for differences in adult patients. Results are discussed with respect to neural models of temporal discounting, dopaminergic alterations in Tourette syndrome and the developmental trajectory of temporal discounting. Specifically, adolescents might show attenuated discounting due to improved inhibitory functions that also affect choice impulsivity and/or the developmental trajectory of executive control functions. Future studies would benefit from a longitudinal approach to further elucidate the developmental trajectory of these effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schueller, Canan Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Ben Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Koerner, Julia Kerner Auch UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Eva UNSPECIFIED orcid.org/0000-0002-2801-0986 UNSPECIFIED Muenchau, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandt, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589830
DOI:	10.1371/journal.pone.0253620
Journal or Publication Title:	PLoS One
Volume:	16
Number:	6
Date:	2021
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELF-CONTROL; DOPAMINERGIC MODULATION; INTERTEMPORAL CHOICE; INHIBITORY CONTROL; DECISION-MAKING; DELAY; REWARD; SCALE; TIME; GRATIFICATION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58983