Tufa, Tafese Beyene, Fuchs, Andre, Orth, Hans Martin, Luebke, Nadine, Knops, Elena, Heger, Eva, Jarso, Godana, Hurissa, Zewdu, Eggers, Yannik, Haeussinger, Dieter, Luedde, Tom, Jensen, Bjoern-Erik Ole, Kaiser, Rolf and Feldt, Torsten (2022). Characterization of HIV-1 drug resistance among patients with failure of second-line combined antiretroviral therapy in central Ethiopia. HIV Med., 23 (2). S. 159 - 169. HOBOKEN: WILEY. ISSN 1468-1293

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Abstract

Background As a consequence of the improved availability of combined antiretroviral therapy (cART) in resource-limited countries, an emergence of HIV drug resistance (HIVDR) has been observed. We assessed the prevalence and spectrum of HIVDR in patients with failure of second-line cART at two HIV clinics in central Ethiopia. Methods HIV drug resistance was analysed in HIV-1-infected patients with virological failure of second-line cART using the geno2pheno application. Results Among 714 patients receiving second-line cART, 44 (6.2%) fulfilled the criteria for treatment failure and 37 were eligible for study inclusion. Median age was 42 years [interquartile range (IQR): 20-45] and 62.2% were male. At initiation of first-line cART, 23 (62.2%) were WHO stage III, mean CD4 cell count was 170.6 (range: 16-496) cells/mu L and median (IQR) HIV-1 viral load was 30 220 (7963-82 598) copies/mL. Most common second-line cART regimens at the time of failure were tenofovir disoproxil fumarate (TDF)-lamivudine (3TC)-ritonavir-boosted atazanavir (ATV/r) (19/37, 51.4%) and zidovudine (ZDV)-3TC-ATV/r (9/37, 24.3%). Genotypic HIV-1 resistance testing was successful in 35 (94.6%) participants. We found at least one resistance mutation in 80% of patients and 40% carried a protease inhibitor (PI)-associated mutation. Most common mutations were M184V (57.1%), Y188C (25.7%), M46I/L (25.7%) and V82A/M (25.7%). High-level resistance against the PI ATV (10/35, 28.6%) and lopinavir (LPV) (5/35, 14.3%) was reported. As expected, no resistance mutations conferring integrase inhibitor resistance were detected. Conclusions We found a high prevalence of resistance mutations, also against PIs (40%), as the national standard second-line cART components. Resistance testing before switching to second- or third-line cART is warranted.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tufa, Tafese BeyeneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orth, Hans MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luebke, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knops, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heger, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarso, GodanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hurissa, ZewduUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eggers, YannikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeussinger, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luedde, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, Bjoern-Erik OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feldt, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-592201
DOI: 10.1111/hiv.13176
Journal or Publication Title: HIV Med.
Volume: 23
Number: 2
Page Range: S. 159 - 169
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1293
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMMUNODEFICIENCY-VIRUS TYPE-1; SUB-SAHARAN AFRICA; HIGH-PREVALENCE; MUTATIONS; OUTCOMESMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59220

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