Universität zu Köln

Filser, Melanie, Baetge, Sharon Jean, Balloff, Carolin, Buchner, Axel, Fink, Gereon Rudolf, Heibel, Markus, Meier, Uwe, Rau, Daniela, Renner, Alina, Schreiber, Herbert, Ullrich, Sebastian and Penner, Iris-Katharina (2021). Mental symptoms in MS (MeSyMS): Development and validation of a new assessment. Mult. Scler. Relat. Disord., 49. OXFORD: ELSEVIER SCI LTD. ISSN 2211-0356

Full text not available from this repository.

Abstract

Background: Patients with Multiple Sclerosis (MS) have an increased risk of suffering from mental and neuropsychiatric symptoms. So far, a fundamental problem in the clinical care of MS patients is that these symptoms are underdiagnosed and, as a consequence, often remain untreated. Present assessment tools have not been developed to be applied in patients with MS. This study aims to develop and validate a new questionnaire to identify disease-related mental symptoms in MS patients. Methods: A questionnaire has been developed by including the following subscales: social and emotional health problems, anxiety, and depression. To evaluate test quality and internal consistency, an item analysis has been conducted. After matching MS patients and control subjects on age and gender, we conducted group comparisons, a Receiver Operating Characteristic (ROC) Curve analysis and a binary logistic regression model. Results: In total, 314 MS patients and 100 matched control subjects were analysed. After performed item analysis, the questionnaire revealed an excellent internal consistency (alpha = 0.94). Compared to control subjects, MS patients showed significant mental health problems in all three dimensions. In comparison to the subscales, the dimension of social and emotional health problems revealed the highest accuracy (AUC = 0.75; d = 0.948) and turned out to be the only scale that reliably differentiated between the groups. Conclusions: MeSyMS constitutes a valid screening instrument to detect mental symptoms in MS. Social and emotional health problems turned out to be the most important aspect when identifying disease-related mental health symptoms in MS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filser, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Baetge, Sharon Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED Balloff, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchner, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Heibel, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Meier, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Rau, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Renner, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiber, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullrich, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Penner, Iris-Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592698
DOI:	10.1016/j.msard.2021.102744
Journal or Publication Title:	Mult. Scler. Relat. Disord.
Volume:	49
Date:	2021
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2211-0356
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIPLE-SCLEROSIS; DEPRESSION; BURDEN; DISORDERS; ANXIETY; COMORBIDITY; VALIDITY; INSIGHTS; COSTS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59269