Universität zu Köln

Kast, Karin, Haefner, Julia, Schroeck, Evelin, Jahn, Arne, Werner, Carmen, Meisel, Cornelia and Wimberger, Pauline . Recommendation and Acceptance of Counselling for Familial Cancer Risk in Newly Diagnosed Breast Cancer Cases. Breast Care. BASEL: KARGER. ISSN 1661-3805

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Abstract

Background: In clinical routine, not every patient who is offered genetic counselling and diagnostics in order to investigate a familial cancer risk predisposition opts for it. Little is known about acceptance of counselling and testing in newly diagnosed breast cancer cases in Germany. Methods: All primary breast cancer cases and patients with DCIS (ductal carcinoma in situ) treated at the University Hospital of Dresden between 2016 and 2019 were included. The number of tumor board recommendations for genetic counselling on the basis of the GC-HBOC risk criteria was recorded. Acceptance was analyzed by number of cases with counselling in the GC-HBOC-Center Dresden. Results: Of 996 primary breast cancer and DCIS cases, 262 (26.3%) were eligible for genetic counselling. Recommendation for genetic counselling was accepted by 64.1% (168/262). Of these 90.5% (152/168) opted for molecular genetic analysis. The acceptance rate for counselling increased between 2016 and 2019 from 58.3 to 72.6%. Altogether, 20.4% (31/152) patients were found to carry a pathogenic variant in the breast cancer genes BRCA1 or BRCA2. Conclusion: Acceptance of recommendation is increasing as clinical consequences augment. Optimization in providing information about hereditary cancer risk and in accessibility of counselling and testing is required to further improve acceptance of recommendation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kast, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Haefner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeck, Evelin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahn, Arne UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisel, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wimberger, Pauline UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592812
DOI:	10.1159/000517021
Journal or Publication Title:	Breast Care
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1661-3805
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA1/2 GERMLINE MUTATIONS; HEREDITARY BREAST; OVARIAN-CANCER; GERMAN CONSORTIUM; REDUCING SURGERY; WOMEN; PREVALENCE; CONSENSUS; SUBTYPES; GENES Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59281