Universität zu Köln

Bey, Katharina, Campos-Martin, Rafael ORCID: 0000-0002-1395-8571, Klawohn, Julia, Reuter, Benedikt, Gruetzmann, Rosa, Riesel, Anja ORCID: 0000-0002-1902-6644, Wagner, Michael ORCID: 0000-0003-2589-6440, Ramirez, Alfredo ORCID: 0000-0003-4991-763X and Kathmann, Norbert . Hypermethylation of the oxytocin receptor gene (OXTR) in obsessive-compulsive disorder: further evidence for a biomarker of disease and treatment response. Epigenetics. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1559-2308

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Abstract

Obsessive-compulsive disorder (OCD) has recently been linked to increased methylation levels in the oxytocin receptor (OXTR) gene, and OXTR hypermethylation has predicted a worse treatment response to cognitive-behavioural therapy (CBT). Furthermore, OCD is associated with childhood trauma and stressful life events, which have both been shown to affect OXTR methylation. Here, we aimed to replicate findings of increased OXTR methylation as a predictor of disease and worse treatment response in an independent sample that received treatment within the public health care system. In addition, we aimed to extend previous findings by examining associations between OXTR hypermethylation, environmental stressors, OCD diagnosis, and treatment response. Methylation levels at two CpGs within OXTR exon III were compared between n = 181 OCD patients and n = 199 healthy controls using linear regression analysis. In a subsample of OCD patients (n = 98) with documented treatment data, we examined associations between methylation and treatment response to CBT. Childhood adversity and stressful life events were assessed using Childhood Trauma Questionnaire and Life Experience Survey, respectively. OCD patients exhibited significant hypermethylation at CpG site cg04523291 compared to controls, and increased methylation was associated with impaired treatment response. Moreover, hypermethylation at cg04523291 was associated with stressful life events in OCD patients, and with childhood adversity in controls. Yet, there were no significant mediation effects. In conclusion, we replicated the association between OXTR hypermethylation and OCD in the largest sample, so far. Furthermore, our findings support the role of OXTR methylation as a promising biomarker for treatment response in OCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bey, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Campos-Martin, Rafael UNSPECIFIED orcid.org/0000-0002-1395-8571 UNSPECIFIED Klawohn, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruetzmann, Rosa UNSPECIFIED UNSPECIFIED UNSPECIFIED Riesel, Anja UNSPECIFIED orcid.org/0000-0002-1902-6644 UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Kathmann, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593326
DOI:	10.1080/15592294.2021.1943864
Journal or Publication Title:	Epigenetics
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1559-2308
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DNA METHYLATION; LIFE EXPERIENCES; SEX-DIFFERENCES; TRAUMA; VASOPRESSIN; EXPOSURE Multiple languages Biochemistry & Molecular Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59332