Universität zu Köln

Sarroca, Sara, Gatius, Alao, Rodriguez-Farre, Eduard ORCID: 0000-0001-9305-3168, Vilchez, David ORCID: 0000-0002-0801-0743, Pallas, Merce, Grinan-Ferre, Christian, Sanfeliu, Coral ORCID: 0000-0002-9004-1206 and Corpas, Ruben ORCID: 0000-0002-7051-1493 (2021). Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms. J. Nutr. Biochem., 89. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4847

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Abstract

Cumulative evidence indicates that excessive consumption of calories from saturated fat contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering and progression of AD pathology induced by a high-fat diet (HFD), and the effects of resveratrol, a polyphenol found in common dietary sources with pleiotropic neuroprotective activities. Over 16 weeks, male wild type (WT) and AD transgenic 5XFAD mice were fed a control diet, HFD (60% kcal from fat), or HFD supplemented with 0.1% resveratrol. Resveratrol protected against HFD-induced memory loss in WT mice and prevented memory loss in 5XFAD mice. Resveratrol also reduced the amyloid burden aggravated by HFD in 5XFAD, and protected against HFD-induced tau pathology in both WT and 5XFAD strains. At the mechanistic level, resveratrol inhibited the HFD-increased amyloidogenic processing of the amyloid precursor protein in both strains; it also restored abnormal high levels in the proteolytic activity of the ubiquitin-proteasome system induced by HFD, suggesting the presence of a compensatory mechanism to counteract the accumulation of aberrant proteins. Thus, our data suggest that resveratrol can correct the harmful effects of HFD in the brain and may be a potential therapeutic agent against obesity-related disorders and AD pathology. (c) 2020 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sarroca, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatius, Alao UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez-Farre, Eduard UNSPECIFIED orcid.org/0000-0001-9305-3168 UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED Pallas, Merce UNSPECIFIED UNSPECIFIED UNSPECIFIED Grinan-Ferre, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanfeliu, Coral UNSPECIFIED orcid.org/0000-0002-9004-1206 UNSPECIFIED Corpas, Ruben UNSPECIFIED orcid.org/0000-0002-7051-1493 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593578
DOI:	10.1016/j.jnutbio.2020.108569
Journal or Publication Title:	J. Nutr. Biochem.
Volume:	89
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-4847
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED PROTEIN-KINASE; COGNITIVE IMPAIRMENT; CALORIC RESTRICTION; NEURON LOSS; AMYLOID HYPOTHESIS; IMPROVES HEALTH; TRANSGENIC MICE; PROTECTIVE ROLE; BRAIN; PROTEASOME Multiple languages Biochemistry & Molecular Biology; Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59357