Universität zu Köln

Castelli, Lucia ORCID: 0000-0002-7701-9733, Elter, Thomas, Wolf, Florian, Watson, Matthew, Schenk, Alexander ORCID: 0000-0002-3122-714X, Steindorf, Karen, Bloch, Wilhelm, Hallek, Michael, Joisten, Niklas ORCID: 0000-0002-9947-8746 and Zimmer, Philipp (2022). Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy. Support. Care Cancer, 30 (1). S. 167 - 177. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Purpose Sleep problems reported by hematological cancer patients are usually linked to higher levels of cancer-related fatigue. Although the awareness of sleep problems in solid cancer patients is rising, there has been less attention to the issue in hematological cancer patients. The present study assesses the differences in sleep by comparing physical activity and fatigue levels among hematological cancer patients during the onset of chemotherapy. Furthermore, it investigates the relationship between sleep, physical activity, and fatigue through mediation analysis. Methods The recruited sample consists of 58 newly diagnosed hematological cancer patients (47.1 +/- 15.4 yrs; 51.7% males). Subjects completed questionnaires assessing sleep (PSQI), physical activity (visual analogue scale), fatigue (MFI-20), anxiety, depression (HADS), and quality of life (EORTC QLQ-C30) within two weeks from starting treatment. Results The sample reported more sleep problems in comparison to the German population norm. The classification as good (ca 25%) or bad sleepers (ca 75%) showed less frequent physical activity (p = .04), higher fatigue (p = .032), anxiety (p = .003), depression (p = .011) and pain (p = .011) in bad sleepers. The mediation analysis revealed significant indirect effects of sleep on fatigue through physical activity habits. Conclusions This study highlights the combined action of sleep problems and physical activity on fatigue during the onset of induction chemotherapy. These two parameters could represent meaningful intervention targets to improve a patient's status during chemotherapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Castelli, Lucia UNSPECIFIED orcid.org/0000-0002-7701-9733 UNSPECIFIED Elter, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Watson, Matthew UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED orcid.org/0000-0002-3122-714X UNSPECIFIED Steindorf, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Niklas UNSPECIFIED orcid.org/0000-0002-9947-8746 UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593636
DOI:	10.1007/s00520-021-06377-5
Journal or Publication Title:	Support. Care Cancer
Volume:	30
Number:	1
Page Range:	S. 167 - 177
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYELOID-LEUKEMIA; HOSPITAL ANXIETY; QUALITY INDEX; EXERCISE; INSTRUMENT; DEPRESSION; DISTURBANCE; SURVIVAL; DURATION; QLQ-C30 Multiple languages Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59363