Universität zu Köln

Rahn, Anne Christin, Wenzel, Lisa, Icks, Andrea, Stahmann, Alexander, Scheiderbauer, Jutta, Grentzenberg, Kristina, Vomhof, Markus, Montalbo, Joseph, Friede, Tim ORCID: 0000-0001-5347-7441, Heesen, Christoph and Koepke, Sascha (2021). Development and evaluation of an interactive web-based decision-making programme on relapse management for people with multiple sclerosis (POWER@MS2)-study protocol for a randomised controlled trial. Trials, 22 (1). LONDON: BMC. ISSN 1745-6215

Full text not available from this repository.

Abstract

Introduction Multiple sclerosis is a chronic inflammatory, degenerative disease of the central nervous system manifesting at first with relapses in about 85% of cases. In Germany, intravenous therapy with high-dose corticosteroids is the treatment standard of acute relapses. The treatment leads to a faster reduction of symptoms in about 25 of 100 treated patients but has no proven long-term benefits over placebo treatment. Intravenous treatment is not superior to oral treatment. Therefore, informed decisions on relapse management are required. An earlier randomised controlled trial showed that evidence-based patient information and education on relapse management leads to more informed decisions and more relapses not treated or treated with oral corticosteroids. This study aims to evaluate whether a web-based relapse management programme will positively change relapse management and strengthen autonomy in people with multiple sclerosis. Methods The pragmatic double-blind randomised controlled trial is accompanied by a mixed-methods process evaluation and a health economic evaluation and follows the UK Medical Research Council guidance on developing and evaluating complex interventions. A total of 188 people with possible or relapsing-remitting multiple sclerosis with >= 1 relapse within the last year and/or >= 2 relapses within the last 2 years will be recruited and randomised using blocks. The intervention group receives a web- and dialogue-based decision aid on relapse management, a nurse-led webinar and access to a monitored chat forum. The control group receives standard information, which will be made available via the same online platform as the intervention. The primary endpoint is the proportion of relapses not treated or treated with oral corticosteroids. Key secondary endpoints are the annualised relapse rate, decision-making, empowerment, quality of life and cost-effectiveness. Facilitators and barriers will be assessed by mixed-methods process evaluation measures. The study ends when 81 relapses have been documented or after 24 months of observation per individual patient. Analyses will follow the intention-to-treat principle. Discussion We hypothesise that the intervention will enhance patient empowerment and have a positive impact on patients' relapse management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rahn, Anne Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Icks, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Stahmann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheiderbauer, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Grentzenberg, Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Vomhof, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Montalbo, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Friede, Tim UNSPECIFIED orcid.org/0000-0001-5347-7441 UNSPECIFIED Heesen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Koepke, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593660
DOI:	10.1186/s13063-021-05059-1
Journal or Publication Title:	Trials
Volume:	22
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1745-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATIENT ACTIVATION MEASURE; DISEASE-MODIFYING THERAPY; EDUCATION-PROGRAM; PLANNED BEHAVIOR; INFORMATION; DEPRESSION; QUESTIONNAIRE; EMPOWERMENT; VALIDATION Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59366