Universität zu Köln

Grill, Sabine, Yahiaoui-Doktor, Maryam, Basrai, Maryam, Struck, Joachim, Schulte, Janin, Berling-Ernst, Anika, Engel, Christoph ORCID: 0000-0002-7247-282X, Ullrich, Mirjam, Lammert, Jacqueline, Bischoff, Stephan C., Schmidt, Thorsten, Niederberger, Uwe ORCID: 0000-0003-3099-0183, Chronas, Dimitrios, Rhiem, Kerstin, Schmutzler, Rita, Halle, Martin and Kiechle, Marion (2021). Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers. Breast Cancer Res. Treat., 186 (3). S. 741 - 753. NEW YORK: SPRINGER. ISSN 1573-7217

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Abstract

Background Germline BRCA1/2 mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)-involved in tumorigenesis and obesity-related diseases-are of interest. We wanted to know whether these biomarkers differ between gBMC and women from the general population and what effect a 1-year lifestyle-intervention has in gBMC. Methods The stable precursor fragments pro-NT and pro-ENK were measured at study entry (SE), after 3 and 12 months for 68 women from LIBRE-1 (a controlled lifestyle-intervention feasibility trial for gBMC involving structured endurance training and the Mediterranean Diet). The SE values were compared with a cohort of the general population including female subjects with and without previous cancer disease, non-suggestive for hereditary breast and ovarian cancer (OMA-reference). For LIBRE-1, we analysed the association between the intervention-related change in the two biomarkers and certain lifestyle factors. Results At SE, gBMC had a higher median pro-NT than OMA-reference (in the subgroups with previous cancer 117 vs. 91 pmol/L, p = 0.002). Non-diseased gBMC had lower median pro-ENK levels when compared to the non-diseased reference group. VO2peak and pro-NT 1-year change in LIBRE-1 were inversely correlated (r = - 0.435; CI - 0.653 to - 0.151; p = 0.004). Pro-ENK correlated positively with VO2peak at SE (r = 0.323; CI 0.061-0.544; p = 0.017). Regression analyses showed an inverse association of 1-year changes for pro-NT and Omega-6/Omega-3 (Estimate: - 37.9, p = 0.097/0.080) in multivariate analysis. Conclusion Our results give first indications for lifestyle-related modification particularly of pro-NT in gBMC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grill, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Yahiaoui-Doktor, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Basrai, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Struck, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Janin UNSPECIFIED UNSPECIFIED UNSPECIFIED Berling-Ernst, Anika UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED orcid.org/0000-0002-7247-282X UNSPECIFIED Ullrich, Mirjam UNSPECIFIED UNSPECIFIED UNSPECIFIED Lammert, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischoff, Stephan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Niederberger, Uwe UNSPECIFIED orcid.org/0000-0003-3099-0183 UNSPECIFIED Chronas, Dimitrios UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Halle, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiechle, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594207
DOI:	10.1007/s10549-020-06070-x
Journal or Publication Title:	Breast Cancer Res. Treat.
Volume:	186
Number:	3
Page Range:	S. 741 - 753
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7217
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59420