Universität zu Köln

Jockel-Schneider, Yvonne, Schlagenhauf, Ulrich, Petsos, Hari, Ruettermann, Stefan, Schmidt, Jana, Ziebolz, Dirk, Wehner, Christian, Laky, Markus, Rott, Thea, Noack, Michael, Noack, Barbara and Lorenz, Katrin (2021). Impact of 0.1% octenidine mouthwash on plaque re-growth in healthy adults: a multi-center phase 3 randomized clinical trial. Clin. Oral Investig., 25 (7). S. 4681 - 4690. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1436-3771

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Abstract

Objectives To investigate plaque inhibition of 0.1% octenidine mouthwash (OCT) vs. placebo over 5 days in the absence of mechanical plaque control. Materials and methods For this randomized, placebo-controlled, double-blind, parallel group, multi-center phase 3 study, 201 healthy adults were recruited. After baseline recording of plaque index (PI) and gingival index (GI), collection of salivary samples, and dental prophylaxis, subjects were randomly assigned to OCT or placebo mouthwash in a 3:1 ratio. Rinsing was performed twice daily for 30 s. Colony forming units in saliva were determined before and after the first rinse. At day 5, PI, GI, and tooth discoloration index (DI) were assessed. Non-parametric van Elteren tests were applied with a significance level of p < 0.05. Results Treatment with OCT inhibited plaque formation more than treatment with placebo (PI: 0.36 vs. 1.29; p < 0.0001). OCT reduced GI (0.04 vs. placebo 0.00; p = 0.003) and salivary bacterial counts (2.73 vs. placebo 0.24 lgCFU/ml; p < 0.0001). Tooth discoloration was slightly higher under OCT (DI: 0.25 vs. placebo 0.00; p = 0.0011). Mild tongue staining and dysgeusia occurred. Conclusions OCT 0.1% mouthwash inhibits plaque formation over 5 days. It therefore can be recommended when regular oral hygiene is temporarily compromised.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jockel-Schneider, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlagenhauf, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Petsos, Hari UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruettermann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziebolz, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Wehner, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Laky, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Rott, Thea UNSPECIFIED UNSPECIFIED UNSPECIFIED Noack, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Noack, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Lorenz, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594241
DOI:	10.1007/s00784-021-03781-3
Journal or Publication Title:	Clin. Oral Investig.
Volume:	25
Number:	7
Page Range:	S. 4681 - 4690
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1436-3771
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59424