Universität zu Köln

Heusser, Karsten ORCID: 0000-0002-2571-5585, Wittkoepper, Judith, Bara, Christoph, Haverich, Axel, Diedrich, Andre, Levine, Benjamin D., Schmitto, Jan D., Jordan, Jens and Tank, Jens (2021). Sympathetic vasoconstrictor activity before and after left ventricular assist device implantation in patients with end-stage heart failure. Eur. J. Heart Fail., 23 (11). S. 1955 - 1960. HOBOKEN: WILEY. ISSN 1879-0844

Full text not available from this repository.

Abstract

Aims Sympathetic overactivity, which predicts poor outcome in patients with heart failure, normalizes following cardiac transplantation. We tested the hypothesis that haemodynamic improvement following left ventricular assist device (LVAD) implantation is also associated with reductions in centrally generated sympathetic activity. Methods and results In eight patients with heart failure (two women, six men, age 44-66 years), we continuously recorded electrocardiogram, beat-to-beat finger blood pressure, respiration, and muscle sympathetic nerve activity (MSNA) before and after implantation of the continuous-flow LVAD devices HeartWare HVAD (n = 4) and HeartMate II (n = 2), and the non-continuous-flow device HeartMate 3 (n = 2). LVAD implantation increased cardiac output by 1.29 +/- 0.88 L/min (P = 0.060) and mean arterial pressure by 16.2 +/- 7.9mmHg (P < 0.001), while reducing pulse pressure by 25.3 +/- 9.8mmHg (P < 0.001). LVAD implantation did not change MSNA burst frequency (-1.3 +/- 7.5 bursts/min, P = 0.636), total activity (+0.62 +/- 1.83 au, P = 0.369), or normalized activity (+0.63 +/- 4.23, P = 0.685). MSNA burst incidence was decreased (-7.8 +/- 9.3 bursts/100 heart beats, P = 0.049). However, cardiac ectopy altered MSNA bursting patterns that could be mistaken for sympatholysis. Conclusion Implantation of current design LVAD does not consistently normalize sympathetic activity in patients with end-stage heart failure despite haemodynamic improvement.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Wittkoepper, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Bara, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Haverich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Diedrich, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Levine, Benjamin D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitto, Jan D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594611
DOI:	10.1002/ejhf.2344
Journal or Publication Title:	Eur. J. Heart Fail.
Volume:	23
Number:	11
Page Range:	S. 1955 - 1960
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1879-0844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NERVE ACTIVITY; CARDIAC-OUTPUT; PROGNOSIS; PULSATILE; RESPONSES; PRESSURE; THERAPY; SUPPORT; HUMANS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59461