Universität zu Köln

Suzuki-Horiuchi, Yoko, Schmitz, Henning, Barlassina, Carlotta, Eccles, David ORCID: 0000-0003-4634-4995, Sinn, Martina, Ortmeier, Claudia, Moritz, Soren and Gentile, Luca ORCID: 0000-0002-7393-7502 (2021). Transcription Factors Active in the Anterior Blastema of Schmidtea mediterranea. Biomolecules, 11 (12). BASEL: MDPI. ISSN 2218-273X

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Abstract

Regeneration, the restoration of body parts after injury, is quite widespread in the animal kingdom. Species from virtually all Phyla possess regenerative abilities. Human beings, however, are poor regenerators. Yet, the progress of knowledge and technology in the fields of bioengineering, stem cells, and regenerative biology have fostered major advancements in regenerative medical treatments, which aim to regenerate tissues and organs and restore function. Human induced pluripotent stem cells can differentiate into any cell type of the body; however, the structural and cellular complexity of the human tissues, together with the inability of our adult body to control pluripotency, require a better mechanistic understanding. Planarians, with their capacity to regenerate lost body parts thanks to the presence of adult pluripotent stem cells could help providing such an understanding. In this paper, we used a top-down approach to shortlist blastema transcription factors (TFs) active during anterior regeneration. We found 44 TFs-31 of which are novel in planarian-that are expressed in the regenerating blastema. We analyzed the function of half of them and found that they play a role in the regeneration of anterior structures, like the anterior organizer, the positional instruction muscle cells, the brain, the photoreceptor, the intestine. Our findings revealed a glimpse of the complexity of the transcriptional network governing anterior regeneration in planarians, confirming that this animal model is the perfect playground to study in vivo how pluripotency copes with adulthood.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Suzuki-Horiuchi, Yoko UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Barlassina, Carlotta UNSPECIFIED UNSPECIFIED UNSPECIFIED Eccles, David UNSPECIFIED orcid.org/0000-0003-4634-4995 UNSPECIFIED Sinn, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortmeier, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Moritz, Soren UNSPECIFIED UNSPECIFIED UNSPECIFIED Gentile, Luca UNSPECIFIED orcid.org/0000-0002-7393-7502 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595885
DOI:	10.3390/biom11121782
Journal or Publication Title:	Biomolecules
Volume:	11
Number:	12
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-273X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLURIPOTENT STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION; PLANARIAN REGENERATION; EYE REGENERATION; EXCRETORY SYSTEM; MUSCLE-FIBERS; MAINTENANCE; DIFFERENTIATION; SPECIFICATION Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59588