Schmitz, Henning ORCID: 0000-0001-6143-1187, Rabe, Moritz ORCID: 0000-0002-7085-4066, Janssens, Guillaume ORCID: 0000-0001-9553-6024, Bondesson, David ORCID: 0000-0003-3112-886X, Rit, Simon ORCID: 0000-0003-2530-1013, Parodi, Katia ORCID: 0000-0001-7779-6690, Belka, Claus, Dinkel, Julien, Kurz, Christopher, Kamp, Florian and Landry, Guillaume (2021). Validation of proton dose calculation on scatter corrected 4D cone beam computed tomography using a porcine lung phantom. Phys. Med. Biol., 66 (17). BRISTOL: IOP PUBLISHING LTD. ISSN 1361-6560

Full text not available from this repository.

Abstract

Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCT(cor)), which can be used for proton dose calculation. 4DCT and 4DCBCT scans of a porcine lung phantom, which generated reproducible ventilation, were acquired with matching breathing patterns. Diffeomorphic Morphons, a deformable image registration algorithm, was used to register the mid-position 4DCT to the mid-position 4DCBCT and yield a 4DvCT. The 4DCBCT was reconstructed using motion-aware reconstruction based on spatial and temporal regularization (MA-ROOSTER). Successively for each phase, digitally reconstructed radiographs of the 4DvCT, simulated without scatter, were exploited to correct scatter in the corresponding CBCT projections. The 4DCBCT(cor) was then reconstructed with MA-ROOSTER using the corrected CBCT projections and the same settings and deformation vector fields as those already used for reconstructing the 4DCBCT. The 4DCBCT(cor) and the 4DvCT were evaluated phase-by-phase, performing proton dose calculations and comparison to those of a ground truth 4DCT by means of dose-volume-histograms (DVH) and gamma pass-rates (PR). For accumulated doses, DVH parameters deviated by at most 1.7% in the 4DvCT and 2.0% in the 4DCBCT(cor) case. The gamma PR for a (2%, 2 mm) criterion with 10% threshold were at least 93.2% (4DvCT) and 94.2% (4DCBCT(cor)), respectively. The 4DCBCT(cor) technique enabled accurate proton dose calculation, which indicates the potential for applicability to clinical 4DCBCT scans.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmitz, HenningUNSPECIFIEDorcid.org/0000-0001-6143-1187UNSPECIFIED
Rabe, MoritzUNSPECIFIEDorcid.org/0000-0002-7085-4066UNSPECIFIED
Janssens, GuillaumeUNSPECIFIEDorcid.org/0000-0001-9553-6024UNSPECIFIED
Bondesson, DavidUNSPECIFIEDorcid.org/0000-0003-3112-886XUNSPECIFIED
Rit, SimonUNSPECIFIEDorcid.org/0000-0003-2530-1013UNSPECIFIED
Parodi, KatiaUNSPECIFIEDorcid.org/0000-0001-7779-6690UNSPECIFIED
Belka, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinkel, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurz, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamp, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landry, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-595913
DOI: 10.1088/1361-6560/ac16e9
Journal or Publication Title: Phys. Med. Biol.
Volume: 66
Number: 17
Date: 2021
Publisher: IOP PUBLISHING LTD
Place of Publication: BRISTOL
ISSN: 1361-6560
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CBCT IMAGE REGISTRATION; CORRECTION ALGORITHM; RESPIRATORY MOTION; THERAPY; CT; CANCER; HEAD; RADIOTHERAPY; PATIENT; RANGEMultiple languages
Engineering, Biomedical; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59591

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item