Universität zu Köln

Torabi, Saeed, Arjomandi Rad, Arian, Vardanyan, Robert, Lopuszko, Aleksandra T., Van den Eynde, Jef ORCID: 0000-0002-5606-376X, Zubarevich, Alina ORCID: 0000-0002-2444-5747, Sa, Michel P. B. O., Szczechowicz, Marcin and Weymann, Alexander (2021). Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis. J. Card. Surg., 36 (7). S. 2476 - 2486. HOBOKEN: WILEY. ISSN 1540-8191

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Abstract

Introduction Primary cardiac sarcomas (PCSs) are an extremely rare and aggressive type of malignancies that have been described only by a limited number of observational studies. This study aimed to evaluate the currently existing evidence comparing surgical to multimodality treatment of PCS. Methods We systematically reviewed Embase, MEDLINE, Cochrane Database, and Google Scholar, from inception to December 2020, for original articles about surgical and multimodality treatment of PCS. The outcomes included were mortality at various time points, resection margin status, and mean estimated survival. The pooled treatment effects were calculated using a random-effects model. Results Ten studies including a total of 1570 patients met our inclusion criteria. Surgery was associated with significantly lower mortality when compared to conservative treatment at 1, 2, and 3 years, whereas no significant difference was found at 5 years. Furthermore, multimodality treatment showed significantly lower mortality at 1 year when compared to surgery alone, but not at 2 and 5 years. We found no difference in mortality between angiosarcomas and other PCS subtypes. Conclusion Overall, surgery was found to provide a significant mortality advantage to PCS patients up to 3 years following treatment. Multimodality treatment might be of additional benefit, although only within the first year. Prospective randomized studies are needed to further explore these differences in the treatment of PCS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Torabi, Saeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Arjomandi Rad, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Vardanyan, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Lopuszko, Aleksandra T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van den Eynde, Jef UNSPECIFIED orcid.org/0000-0002-5606-376X UNSPECIFIED Zubarevich, Alina UNSPECIFIED orcid.org/0000-0002-2444-5747 UNSPECIFIED Sa, Michel P. B. O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Szczechowicz, Marcin UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596246
DOI:	10.1111/jocs.15538
Journal or Publication Title:	J. Card. Surg.
Volume:	36
Number:	7
Page Range:	S. 2476 - 2486
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1540-8191
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Cardiac & Cardiovascular Systems; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59624