Universität zu Köln

Demir, Fatih ORCID: 0000-0002-5744-0205, Troldborg, Anne ORCID: 0000-0002-9501-1268, Thiel, Steffen ORCID: 0000-0002-4817-155X, Lasse, Moritz, Huesgen, Pitter F., Tomas, Nicola M., Wiech, Thorsten and Rinschen, Markus M. (2021). Proteolysis and inflammation of the kidney glomerulus. Cell Tissue Res., 385 (2). S. 489 - 501. NEW YORK: SPRINGER. ISSN 1432-0878

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Abstract

Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases, lupus nephritis, and membranous nephropathy, we portrait two proteolytic pathomechanisms and the role of the complement system. We discuss how profiling proteolytic activity in patient samples could be used to stratify patients for more targeted interventions in inflammatory kidney diseases. We also describe novel comprehensive, quantitative tools to investigate the entirety of proteolytic processes in a tissue sample. Emphasis is placed on mass spectrometric approaches that enable the comprehensive analysis of the complement system, as well as protease activities and regulation in general.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Demir, Fatih UNSPECIFIED orcid.org/0000-0002-5744-0205 UNSPECIFIED Troldborg, Anne UNSPECIFIED orcid.org/0000-0002-9501-1268 UNSPECIFIED Thiel, Steffen UNSPECIFIED orcid.org/0000-0002-4817-155X UNSPECIFIED Lasse, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Huesgen, Pitter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomas, Nicola M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiech, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Rinschen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596311
DOI:	10.1007/s00441-021-03433-8
Journal or Publication Title:	Cell Tissue Res.
Volume:	385
Number:	2
Page Range:	S. 489 - 501
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0878
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59631