Universität zu Köln

Sauerbier, Anna, Schrag, Anette, Brown, Richard, Martinez-Martin, Pablo, Aarsland, Dag ORCID: 0000-0001-6314-216X, Mulholland, Nicola ORCID: 0000-0003-0912-9890, Vivian, Gill, Dafsari, Haidar S., Rizos, Alexandra, Corcoran, Ben, Jarosz, Jozef, Siakallis, Loizos and Chaudhuri, K. Ray (2021). Clinical Non-Motor Phenotyping of Black and Asian Minority Ethnic Compared to White Individuals with Parkinson's Disease Living in the United Kingdom. J. Parkinsons Dis., 11 (1). S. 299 - 308. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Ethnic phenotypic differences in Parkinson's disease (PD) are important to understand the heterogeneity of PD and develop biomarkers and clinical trials. Objective: To investigate (i) whether there are non-motor symptoms (NMS)- and comorbidity-based phenotypic differences between Black, Asian and Minority Ethnic (BAME) and White PD patients and (ii) whether clinically available biomarkers may help differentiate and explain the differences between the groups. Methods: This is a multicentre (four sites, London), real-life, cross-sectional study including PD patients of BAME or White ethnicity. The primary outcome was a detailed NMS assessment; additional measurements included disease and motor stage, comorbidity, sociodemographic parameters and brain MRI imaging. Results: 271 PD patients (54 Asian, 71 Black, and 146 White) were included balanced for age, gender, and disease severity (HY). Black patients had a shorter disease duration compared to White and Asian populations. The SCOPA-Motor activities of daily living scores as well as the NMSS scores were significantly higher in both Black (total score and domain miscellaneous) and Asian (total score and domains sleep/fatigue, mood/apathy and perception/hallucinations) than White individuals. Both BAME populations had higher prevalence of arterial hypertension, and the Black population had a higher prevalence of diabetes mellitus. Brain MRI revealed a greater severity of white matter changes in Black compared to the White and Asian cohorts. Conclusion: These findings suggest differences in phenotype of PD in BAME populations with greater burden of NMS and motor disability and a higher rate of cardiovascular comorbidities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sauerbier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrag, Anette UNSPECIFIED UNSPECIFIED UNSPECIFIED Brown, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Aarsland, Dag UNSPECIFIED orcid.org/0000-0001-6314-216X UNSPECIFIED Mulholland, Nicola UNSPECIFIED orcid.org/0000-0003-0912-9890 UNSPECIFIED Vivian, Gill UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Corcoran, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Jarosz, Jozef UNSPECIFIED UNSPECIFIED UNSPECIFIED Siakallis, Loizos UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596492
DOI:	10.3233/JPD-202218
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	11
Number:	1
Page Range:	S. 299 - 308
Date:	2021
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MINI-MENTAL-STATE; SCALE; DEPRESSION; SLEEP; AGE; DIAGNOSIS; FATIGUE; PAIN Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59649