Villaescusa, Patricia 
ORCID: 0000-0001-6010-0343, Seidel, Maria, Nothnagel, Michael ORCID: 0000-0001-8305-7114, Pinotti, Thomaz, Gonzalez-Andrade, Fabricio, Alvarez-Gila, Oscar, de Pancorbo, Marian M. and Roewer, Lutz ORCID: 0000-0001-9383-4941
(2021).
A Y-chromosomal survey of Ecuador 's multi-ethnic population reveals new insights into the tri-partite population structure and supports an early Holocene age of the rare Native American founder lineage C3-MPB373.
Forensic Sci. Int.-Genet., 51.
CLARE:
ELSEVIER IRELAND LTD.
ISSN 1878-0326
Abstract
Ecuador is a multiethnic and pluricultural country with a complex history defined by migration and admixture processes. The present study aims to increase our knowledge on the Ecuadorian Native Amerindian groups and the unique South American Y-chromosome haplogroup C3-MPB373 through the analysis of up to 23 Y-chromosome STRs (Y-STRs) and several Y-SNPs in a sample of 527 Ecuadorians from 7 distinct populations and geographic areas, including Kichwa and non-Kichwa Native Amerindians, Mestizos and Afro-Ecuadorians. Our results reveal the presence of C3-MPB373 both in the Amazonian lowland Kichwa with frequencies up to 28 % and, for the first time, in notable proportions in Kichwa populations from the Ecuadorian highlands. The substantially higher frequencies of C3-MPB373 in the Amazonian lowlands found in Kichwa and Waorani individuals suggest a founder effect in that area. Notably, estimates for the time to the most recent common ancestor (TMRCA) in the range of 7.2-9.0 kya point to an ancient origin of the haplogroup and suggest an early Holocene expansion of C3-MPB373 into South America. Finally, the pairwise genetic distances (R-ST) separate the Kichwa Salasaka from all the other Native Amerindian and Ecuadorian groups, indicating a so far hidden diversity among the Kichwa-speaking populations and suggesting a more southern origin of this population. In sum, our study provides a more in-depth knowledge of the male genetic structure of the multiethnic Ecuadorian population, as well as a valuable reference dataset for forensic use.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-596591 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.fsigen.2020.102427 | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Forensic Sci. Int.-Genet. | ||||||||||||||||||||||||||||||||||||
| Volume: | 51 | ||||||||||||||||||||||||||||||||||||
| Date: | 2021 | ||||||||||||||||||||||||||||||||||||
| Publisher: | ELSEVIER IRELAND LTD | ||||||||||||||||||||||||||||||||||||
| Place of Publication: | CLARE | ||||||||||||||||||||||||||||||||||||
| ISSN: | 1878-0326 | ||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/59659 |
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