Universität zu Köln

Hammes, Jochen, Bischof, Gerard N., Bohn, Karl P., Onur, Oezguer, Schneider, Anja ORCID: 0000-0001-9540-8700, Fliessbach, Klaus, Hoenig, Merle C., Jessen, Frank, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Drzezga, Alexander ORCID: 0000-0001-6018-716X and van Eimeren, Thilo ORCID: 0000-0002-6951-2325 (2021). One-Stop Shop: F-18-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases. J. Nucl. Med., 62 (2). S. 240 - 247. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Tau protein aggregations are a hallmark of amyloid-associated Alzheimer disease and some forms of non-amyloid-associated frontotemporal lobar degeneration. In recent years, several tracers for in vivo tau imaging have been under evaluation. This study investigated the ability of F-18-flortaucipir PET not only to assess tau positivity but also to differentiate between amyloid-positive and-negative forms of neurodegeneration on the basis of different F-18-flortaucipir PET signatures. Methods: The F-18-flortaucipir PET data of 35 patients with amyloid-positive neurodegeneration, 19 patients with amyloidnegative neurodegeneration, and 17 healthy controls were included in a data-driven scaled subprofile model (SSM)/principal-component analysis (PCA) identifying spatial covariance patterns. SSM/PCA pattern expression strengths were tested for their ability to predict amyloid status in a receiver-operating-characteristic analysis and validated with a leave-one-out approach. Results: Pattern expression strengths predicted amyloid status with a sensitivity of 0.94 and a specificity of 0.83. A support vector machine classification based on pattern expression strengths in 2 different SSM/PCA components yielded a prediction accuracy of 98%. Anatomically, prediction performance was driven by parietooccipital gray matter in amyloid-positive patients versus predominant white matter binding in amyloid-negative patients. Conclusion: SSM/PCA-derived binding patterns of F-18-flortaucipir differentiate between amyloid-positive and-negative neurodegenerative diseases with high accuracy. F-18-flortaucipir PET alone may convey additional information equivalent to that from amyloid PET. Together with a perfusion-weighted early-phase acquisition (F-18-FDG PET-equivalent), a single scan potentially contains comprehensive information on amyloid (A), tau (T), and neurodegeneration (N) status as required by recent biomarker classification algorithms (A/T/N).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bohn, Karl P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenig, Merle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596681
DOI:	10.2967/jnumed.120.244061
Journal or Publication Title:	J. Nucl. Med.
Volume:	62
Number:	2
Page Range:	S. 240 - 247
Date:	2021
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TAU; NEUROPATHOLOGY; NETWORKS; BRAIN Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59668