Universität zu Köln

Draganova, Rossitza, Konietschke, Frank, Steiner, Katharina M., Elangovan, Naveen, Guemues, Meltem, Goericke, Sophia M., Ernst, Thomas M. ORCID: 0000-0002-2170-9241, Deistung, Andreas, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Konczak, Juergen and Timmann, Dagmar (2022). Motor training-related brain reorganization in patients with cerebellar degeneration. Hum. Brain Mapp., 43 (5). S. 1611 - 1630. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Cerebellar degeneration progressively impairs motor function. Recent research showed that cerebellar patients can improve motor performance with practice, but the optimal feedback type (visual, proprioceptive, verbal) for such learning and the underlying neuroplastic changes are unknown. Here, patients with cerebellar degeneration (N = 40) and age- and sex-matched healthy controls (N = 40) practiced single-joint, goal-directed forearm movements for 5 days. Cerebellar patients improved performance during visuomotor practice, but a training focusing on either proprioceptive feedback, or explicit verbal feedback and instruction did not show additional benefits. Voxel-based morphometry revealed that after training gray matter volume (GMV) was increased prominently in the visual association cortices of controls, whereas cerebellar patients exhibited GMV increase predominantly in premotor cortex. The premotor cortex as a recipient of cerebellar efferents appears to be an important hub in compensatory remodeling following damage of the cerebro-cerebellar motor system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Draganova, Rossitza UNSPECIFIED UNSPECIFIED UNSPECIFIED Konietschke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, Katharina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elangovan, Naveen UNSPECIFIED UNSPECIFIED UNSPECIFIED Guemues, Meltem UNSPECIFIED UNSPECIFIED UNSPECIFIED Goericke, Sophia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Thomas M. UNSPECIFIED orcid.org/0000-0002-2170-9241 UNSPECIFIED Deistung, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Konczak, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmann, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597353
DOI:	10.1002/hbm.25746
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	43
Number:	5
Page Range:	S. 1611 - 1630
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIRECT-CURRENT STIMULATION; CYTOARCHITECTONIC AREAS; PREMOTOR CORTEX; BASAL GANGLIA; ATAXIA; ADAPTATION; PERCEPTION; MOVEMENT; EXPLICIT; CONNECTIVITY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59735