Universität zu Köln

Eberhardt, Kirsten Alexandra, Sarfo, Fred Stephen, Klupp, Eva-Maria, Dompreh, Albert, Di Cristanziano, Veronica, Kuffour, Edmund Osei, Boateng, Richard, Norman, Betty ORCID: 0000-0002-4075-5972, Phillips, Richard Odame ORCID: 0000-0001-8992-0222, Aepfelbacher, Martin and Feldt, Torsten (2021). Intestinal Colonization with Tropheryma whipplei-Clinical and Immunological Implications for HIV Positive Adults in Ghana. Microorganisms, 9 (8). BASEL: MDPI. ISSN 2076-2607

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Abstract

Background: Recent studies demonstrated higher prevalence rates of Tropheryma whipplei (T. whipplei) in HIV positive than in HIV negative subjects. However, associations with the immune status in HIV positive participants were conflicting. Methods: For this cross-sectional study, stool samples of 906 HIV positive and 98 HIV negative individuals in Ghana were tested for T. whipplei. Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and laboratory parameters were assessed. Results: The prevalence of T. whipplei was 5.85% in HIV positive and 2.04% in HIV negative participants. Within the group of HIV positive participants, the prevalence reached 7.18% in patients without co-trimoxazole prophylaxis, 10.26% in subjects with ART intake, and 12.31% in obese participants. Frequencies of clinical symptoms were not found to be higher in HIV positive T. whipplei carriers compared to T. whipplei negative participants. Markers of immune activation were lower in patients colonized with T. whipplei. Multivariate regression models demonstrated an independent relationship of a high CD4+ T cell count, a low HIV-1 viral load, and an obese body weight with the presence of T. whipplei. Conclusions: Among HIV positive individuals, T. whipplei colonization was associated with a better immune status but not with clinical consequences. Our data suggest that the withdrawal of co-trimoxazole chemoprophylaxis among people living with HIV on stable cART regimen may inadvertently increase the propensity towards colonization with T. whipplei.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eberhardt, Kirsten Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarfo, Fred Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Klupp, Eva-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Dompreh, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuffour, Edmund Osei UNSPECIFIED UNSPECIFIED UNSPECIFIED Boateng, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Norman, Betty UNSPECIFIED orcid.org/0000-0002-4075-5972 UNSPECIFIED Phillips, Richard Odame UNSPECIFIED orcid.org/0000-0001-8992-0222 UNSPECIFIED Aepfelbacher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldt, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597645
DOI:	10.3390/microorganisms9081781
Journal or Publication Title:	Microorganisms
Volume:	9
Number:	8
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-2607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATHOGENESIS; PREVALENCE; DIARRHEA; DISEASE Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59764