Eichenauer, Dennis A. ORCID: 0000-0002-1927-3514, Buhnen, Ina, Kreissl, Stefanie, Goergen, Helen, Fuchs, Michael, von Tresckow, Bastian, Rosenwald, Andreas, Klapper, Wolfram, Hansmann, Martin-Leo, Moller, Peter, Bernd, Heinz-Wolfram, Feller, Alfred C., Engert, Andreas, Borchmann, Peter and Hartmann, Sylvia (2022). Histopathological growth patterns in patients with advanced nodular lymphocyte-predominant Hodgkin lymphoma treated within the randomized HD18 study: a report from the German Hodgkin Study Group. Br. J. Haematol., 196 (1). S. 99 - 105. HOBOKEN: WILEY. ISSN 1365-2141

Full text not available from this repository.

Abstract

We retrospectively investigated histopathological growth patterns in individuals with advanced nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) treated within the randomized HD18 study. In all, 35/60 patients (58%) presented with atypical growth patterns. Patients with atypical growth patterns more often had stage IV disease (P = 0 center dot 0354) and splenic involvement (P = 0 center dot 0048) than patients with typical growth patterns; a positive positron emission tomography after two cycles of chemotherapy (PET-2) tended to be more common (P = 0 center dot 1078). Five-year progression-free survival [hazard ratio (HR) = 0 center dot 86; 95% confidence interval (CI) = 0 center dot 49-1 center dot 47] and overall survival (HR = 0 center dot 85; 95% CI = 0 center dot 49-1 center dot 51) did not differ between the groups after study treatment with PET-2-guided escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). Thus, advanced NLPHL is often associated with atypical growth patterns but their prognostic impact is compensated by PET-2-guided escalated BEACOPP.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Eichenauer, Dennis A.UNSPECIFIEDorcid.org/0000-0002-1927-3514UNSPECIFIED
Buhnen, InaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreissl, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goergen, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Tresckow, BastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenwald, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klapper, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansmann, Martin-LeoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moller, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernd, Heinz-WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feller, Alfred C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borchmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-597987
DOI: 10.1111/bjh.17770
Journal or Publication Title: Br. J. Haematol.
Volume: 196
Number: 1
Page Range: S. 99 - 105
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1365-2141
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSFORMATIONMultiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59798

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item