Galldiks, Norbert, Abdulla, Diana S. Y., Scheffler, Matthias, Wolpert, Fabian, Werner, Jan-Michael ORCID: 0000-0001-7147-4594, Huellner, Martin, Stoffels, Gabriele, Schweinsberg, Viola, Schlaak, Max, Kreuzberg, Nicole, Landsberg, Jennifer, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Ceccon, Garry, Baues, Christian, Trommer, Maike, Celik, Eren, Ruge, Maximilian, I, Kocher, Martin, Marnitz, Simone, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Tonn, Joerg-Christian, Weller, Michael, Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Wolf, Juergen and Mauch, Cornelia (2021). Treatment Monitoring of Immunotherapy and Targeted Therapy Using F-18-FET PET in Patients with Melanoma and Lung Cancer Brain Metastases: Initial Experiences. J. Nucl. Med., 62 (4). S. 464 - 471. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

We investigated the value of O-(2-F-18-fluoroethyl)-L-tyrosine ((18) F-FET) PET for treatment monitoring of immune checkpoint inhibition (ICI) or targeted therapy (TT) alone or in combination with radiotherapy in patients with brain metastasis (BM) since contrast-enhanced MRI often remains inconclusive. Methods: We retrospectively identified 40 patients with 107 BMs secondary to melanoma (n = 29 with 75 BMs) or non-small cell lung cancer (n = 11 with 32 BMs) treated with ICI or TT who had F-18-FET PET (n = 60 scans) for treatment monitoring from 2015 to 2019. Most patients (n = 37; 92.5%) had radiotherapy during the course of the disease. In 27 patients, 18 FFET PET was used to differentiate treatment-related changes from BM relapse after ICI or TT. In 13 patients, F-18-FET PET was performed for response assessment to ICI or TT using baseline and follow-up scans (median time between scans, 4.2 mo). In all lesions, static and dynamic F-18-FET PET parameters were obtained (i.e., mean tumor-to-brain ratios [TBR], time-to-peak values). Diagnostic accuracies of PET parameters were evaluated by receiver-operating-characteristic analyses using the clinical follow-up or neuropathologic findings as a reference. Results: A TBR threshold of 1.95 differentiated BM relapse from treatment-related changes with an accuracy of 85% (P = 0.003). Metabolic responders to ICI or TT on F-18-FET PET had a significantly longer stable follow-up (threshold of TBR reduction relative to baseline, >= 10%; accuracy, 82%; P = 0.004). Furthermore, at follow-up, time to peak in metabolic responders increased significantly (P = 0.019). Conclusion: F-18-FET PET may add valuable information for treatment monitoring in BM patients treated with ICI or TT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Galldiks, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abdulla, Diana S. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolpert, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, Jan-MichaelUNSPECIFIEDorcid.org/0000-0001-7147-4594UNSPECIFIED
Huellner, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoffels, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweinsberg, ViolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuzberg, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landsberg, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohmann, PhilippUNSPECIFIEDorcid.org/0000-0002-5360-046XUNSPECIFIED
Ceccon, GarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baues, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trommer, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Celik, ErenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, Maximilian, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marnitz, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Tonn, Joerg-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDorcid.org/0000-0003-1101-5075UNSPECIFIED
Wolf, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauch, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-598733
DOI: 10.2967/jnumed.120.248278
Journal or Publication Title: J. Nucl. Med.
Volume: 62
Number: 4
Page Range: S. 464 - 471
Date: 2021
Publisher: SOC NUCLEAR MEDICINE INC
Place of Publication: RESTON
ISSN: 1535-5667
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; RESPONSE ASSESSMENT; RADIATION NECROSIS; STEREOTACTIC RADIOSURGERY; EUROPEAN ASSOCIATION; C-11-METHIONINE PET; DIAGNOSTIC-ACCURACY; RECURRENT; TUMORS; PSEUDOPROGRESSIONMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59873

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