Universität zu Köln

Scheyerer, Max J., Spiegl, Ulrich J. A., Grueninger, Sebastian, Hartmann, Frank, Katscher, Sebastian, Osterhoff, Georg ORCID: 0000-0001-5051-0998, Perl, Mario, Pumberger, Matthias, Schmeiser, Gregor, Ullrich, Bernhard W. and Schnake, Klaus J. (2022). Risk Factors for Failure in Conservatively Treated Osteoporotic Vertebral Fractures: A Systematic Review. Glob. Spine J., 12 (2). S. 289 - 298. LONDON: SAGE PUBLICATIONS LTD. ISSN 2192-5690

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Abstract

Study Design: Systematic review. Objectives: Osteoporosis is one of the most common diseases of the elderly, whereby vertebral body fractures are in many cases the first manifestation. Even today, the consequences for patients are underestimated. Therefore, early identification of therapy failures is essential. In this context, the aim of the present systematic review was to evaluate the current literature with respect to clinical and radiographic findings that might predict treatment failure. Methods: We conducted a comprehensive, systematic review of the literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) checklist and algorithm. Results: After the literature search, 724 potentially eligible investigations were identified. In total, 24 studies with 3044 participants and a mean follow-up of 11 months (range 6-27.5 months) were included. Patient-specific risk factors were age >73 years, bone mineral density with a t-score <-2.95, BMI >23 and a modified frailty index >2.5. The following radiological and fracture-specific risk factors could be identified: involvement of the posterior wall, initial height loss, midportion type fracture, development of an intravertebral cleft, fracture at the thoracolumbar junction, fracture involvement of both endplates, different morphological types of fractures, and specific MRI findings. Further, a correlation between sagittal spinal imbalance and treatment failure could be demonstrated. Conclusion: In conclusion, this systematic review identified various factors that predict treatment failure in conservatively treated osteoporotic fractures. In these cases, additional treatment options and surgical treatment strategies should be considered in addition to follow-up examinations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheyerer, Max J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spiegl, Ulrich J. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grueninger, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Katscher, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Osterhoff, Georg UNSPECIFIED orcid.org/0000-0001-5051-0998 UNSPECIFIED Perl, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Pumberger, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmeiser, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullrich, Bernhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnake, Klaus J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598755
DOI:	10.1177/2192568220982279
Journal or Publication Title:	Glob. Spine J.
Volume:	12
Number:	2
Page Range:	S. 289 - 298
Date:	2022
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	2192-5690
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AFFECTING PROGRESSIVE COLLAPSE; COMPRESSION FRACTURES; CLASSIFICATION; DEFORMITY; OUTCOMES; IMPACT Multiple languages Clinical Neurology; Orthopedics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59875