Universität zu Köln

Gastaldi, Giacomo ORCID: 0000-0001-6327-7451, Pannier, Felizitas, Roztocil, Karel, Lugli, Marzia, Mansilha, Armando, Haller, Hermann, Rabe, Eberhard and Van Rijn, Marie Josee (2021). Chronic venous disease and diabetic microangiopathy center dot center dot pathophysiology and commonalities. Int. Angiol., 40 (6). S. 457 - 470. TURIN: EDIZIONI MINERVA MEDICA. ISSN 1827-1839

Full text not available from this repository.

Abstract

Chronic venous disease and diabetes mellitus are highly prevalent and debilitating conditions affecting millions of individuals globally. Although these conditions are typically considered as separate entities, they often co-exist which may be important in both understanding their pathophysiology and determining the best treatment strategy. Diabetes mellitus is twice as common in patients with chronic venous disease compared with the general population. Notably, a large proportion of patients with diabetes mellitus present with venous disorders, although this is often overlooked. The etiology of chronic venous disease is multifactorial, involving hemodynamic, genetic, and environmental factors which result in changes to the venous endothelium and structural wall as well as inflammation. Inflammation, endothelial dysfunction and hyperfiltration or leakage, are commonly observed in diabetes mellitus and cause various diabetic microvascular complications. Both diseases are also influenced by the increased expression of adhesion molecules, chemokines, and cytokines, and are characterized by the presence of vessel hypertension. Consequently, despite differences in etiology, the pathophysiology of both chronic venous disease and diabetic microangiopathy appears to be driven by endothelial dysfunction and inflammation. Treatment strategies should take the co-existence of chronic venous disease and diabetic microangiopathy into account. Compression therapy is recommended in inflammatory conditions that have an edema component as seen in both chronic venous disease and diabetes mellitus. Lifestyle changes like weight loss and exercise, will improve metabolic state and lower inflammation and should be promoted in these patients. Additionally, both patient populations may benefit from venoactive drugs. (Cite this article as: Gastaldi G, Pannier F, Roztocil K, Lugli M, Mansilha A, Haller H, et al. Chronic venous disease and diabetic microangiopathy: pathophysiology and commonalities. Int Angiol 2021;40:457-69. DOI: 10.23736/S0392-9590.21.04664-2)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gastaldi, Giacomo UNSPECIFIED orcid.org/0000-0001-6327-7451 UNSPECIFIED Pannier, Felizitas UNSPECIFIED UNSPECIFIED UNSPECIFIED Roztocil, Karel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lugli, Marzia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansilha, Armando UNSPECIFIED UNSPECIFIED UNSPECIFIED Haller, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabe, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Rijn, Marie Josee UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598824
DOI:	10.23736/S0392-9590.21.04664-2
Journal or Publication Title:	Int. Angiol.
Volume:	40
Number:	6
Page Range:	S. 457 - 470
Date:	2021
Publisher:	EDIZIONI MINERVA MEDICA
Place of Publication:	TURIN
ISSN:	1827-1839
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM DOBESILATE PREVENTS; RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; VARICOSE-VEINS; MATRIX METALLOPROTEINASES; POSTTHROMBOTIC-SYNDROME; OXIDATIVE STRESS; INSUFFICIENCY; DISORDERS; INFLAMMATION Multiple languages Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59882