Universität zu Köln

Klein, Pedro Costa, Ettinger, Ulrich, Schirner, Michael ORCID: 0000-0001-8227-8476, Ritter, Petra ORCID: 0000-0002-4643-4782, Rujescu, Dan, Falkai, Peter, Koutsouleris, Nikolaos, Kambeitz-Ilankovic, Lana and Kambeitz, Joseph ORCID: 0000-0002-8988-3959 (2021). Brain Network Simulations Indicate Effects of Neuregulin-1 Genotype on Excitation-Inhibition Balance in Cortical Dynamics. Cereb. Cortex, 31 (4). S. 2013 - 2026. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Neuregulin-1 (NRG1) represents an important factor for multiple processes including neurodevelopment, brain functioning or cognitive functions. Evidence from animal research suggests an effect of NRG1 on the excitation-inhibition (E/I) balance in cortical circuits. However, direct evidence for the importance of NRG1 in E/I balance in humans is still lacking. In this work, we demonstrate the application of computational, biophysical network models to advance our understanding of the interaction between cortical activity observed in neuroimaging and the underlying neurobiology. We employed a biophysical neuronal model to simulate large-scale brain dynamics and to investigate the role of polymorphisms in the NRG1 gene (rs35753505, rs3924999) in n = 96 healthy adults. Our results show that G/G-carriers (rs3924999) exhibit a significant difference in global coupling (P = 0.048) and multiple parameters determining E/I-balance such as excitatory synaptic coupling (P = 0.047), local excitatory recurrence (P = 0.032) and inhibitory synaptic coupling (P = 0.028). This indicates that NRG1 may be related to excitatory recurrence or excitatory synaptic coupling potentially resulting in altered E/I-balance. Moreover, we suggest that computational modeling is a suitable tool to investigate specific biological mechanisms in health and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klein, Pedro Costa UNSPECIFIED UNSPECIFIED UNSPECIFIED Ettinger, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirner, Michael UNSPECIFIED orcid.org/0000-0001-8227-8476 UNSPECIFIED Ritter, Petra UNSPECIFIED orcid.org/0000-0002-4643-4782 UNSPECIFIED Rujescu, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkai, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED orcid.org/0000-0002-8988-3959 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598948
DOI:	10.1093/cercor/bhaa339
Journal or Publication Title:	Cereb. Cortex
Volume:	31
Number:	4
Page Range:	S. 2013 - 2026
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59894