Universität zu Köln

Schwenkenbecher, Philipp, Skripuletz, Thomas, Lange, Peter, Durr, Marc, Konen, Felix F., Mohn, Nora, Ringelstein, Marius, Menge, Til, Friese, Manuel A. ORCID: 0000-0001-6380-2420, Melzer, Nico ORCID: 0000-0002-2420-701X, Malter, Michael P., Hausler, Martin, Thaler, Franziska S., Stangel, Martin, Lewerenz, Jan and Suhs, Kurt-Wolfram (2021). Intrathecal Antibody Production Against Epstein-Barr, Herpes Simplex, and Other Neurotropic Viruses in Autoimmune Encephalitis. Neurol.-Neuroimmunol. Neuroinflammation, 8 (6). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2332-7812

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Abstract

Background and Objectives Neurotropic viruses are suspected to play a role in the pathogenesis of autoimmune diseases of the CNS such as the association between the Epstein-Barr virus (EBV) and multiple sclerosis (MS). A group of autoimmune encephalitis (AE) is linked to antibodies against neuronal cell surface proteins. Because CNS infection with the herpes simplex virus can trigger anti-NMDA receptor (NMDAR) encephalitis, a similar mechanism for EBV and other neurotropic viruses could be postulated. To investigate for previous viral infections of the CNS, intrathecally produced virus-specific antibody synthesis was determined in patients with AE. Methods Antibody-specific indices (AIs) against EBV and measles, rubella, varicella zoster, herpes simplex virus, and cytomegalovirus were determined in 27 patients having AE (anti-NMDAR encephalitis, n = 21, and LGI1 encephalitis, n = 6) and in 2 control groups comprising of 30 patients with MS and 21 patients with noninflammatory CNS diseases (NIND), which were sex and age matched. Results An intrathecal synthesis of antibodies against EBV was found in 5/27 (19%) patients with AE and 2/30 (7%) of the patients with MS. All these patients had also at least 1 additional elevated virus-specific AI. In contrast, in none of the patients with NIND, an elevated virus-specific AI was detected. Discussion Intrathecally produced antibodies against EBV can be found in patients with AE and MS but only together with antibodies against different neurotropic viruses. Evidence of these antibodies is the result of a polyspecific immune response similar yet distinct from MS response rather than an elapsed infection of the CNS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwenkenbecher, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Skripuletz, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Durr, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Konen, Felix F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohn, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Ringelstein, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Menge, Til UNSPECIFIED UNSPECIFIED UNSPECIFIED Friese, Manuel A. UNSPECIFIED orcid.org/0000-0001-6380-2420 UNSPECIFIED Melzer, Nico UNSPECIFIED orcid.org/0000-0002-2420-701X UNSPECIFIED Malter, Michael P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Thaler, Franziska S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stangel, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewerenz, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Suhs, Kurt-Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599580
DOI:	10.1212/NXI.0000000000001062
Journal or Publication Title:	Neurol.-Neuroimmunol. Neuroinflammation
Volume:	8
Number:	6
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2332-7812
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIPLE-SCLEROSIS; CEREBROSPINAL-FLUID; IMMUNOGLOBULIN-SYNTHESIS; IMMUNE-RESPONSE; DIAGNOSIS; SERUM; RISK; PATTERNS; PART Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59958