Universität zu Köln

Heinzelmann, Sonja, Boehringer, Daniel, Maier, Philip Christian, Seitz, Berthold ORCID: 0000-0001-9701-8204, Cursiefen, Claus, Maier, Anna-Karina B., Dietrich-Ntoukas, Tina, Geerling, Gerd, Viestenz, Arne, Pfeiffer, Norbert and Reinhard, Thomas (2021). Survey of Rejection Prophylaxis Following Suture Removal in Penetrating Keratoplasty in Germany. Klinische Monatsblat. Augenheilkunde, 238 (5). S. 591 - 598. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background Penetrating keratoplasty (PK) gets more and more reserved to cases of increasing complexity. In such cases, ocular comorbidities may limit graft survival following PK. A major cause for graft failure is endothelial graft rejection. Suture removal is a known risk factor for graft rejection. Nevertheless, there is no evidence-based regimen for rejection prophylaxis following suture removal. Therefore, a survey of rejection prophylaxis was conducted at 7 German keratoplasty centres. Objective The aim of the study was documentation of the variability of medicinal aftercare following suture removal in Germany. Methods Seven German keratoplasty centres with the highest numbers for PK were selected. The centres were sent a survey consisting of half-open questions. The centres performed a mean of 140 PK in 2018. The return rate was 100%. The findings were tabulated. Results All centres perform a double-running cross-stitch suture for standard PK, as well as a treatment for rejection prophylaxis with topical steroids after suture removal. There are differences in intensity (1-5 times daily) and tapering (2-20 weeks) of the topical steroids following suture removal. Two centres additionally use systemic steroids for a few days. Discussion Rejection prophylaxis following PK is currently poorly standardised and not evidence-based. All included centres perform medical aftercare following suture removal. It is assumed that different treatment strategies show different cost-benefit ratios. In the face of the diversity, a systematic analysis is required to develop an optimised regimen for all patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heinzelmann, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehringer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Philip Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Seitz, Berthold UNSPECIFIED orcid.org/0000-0001-9701-8204 UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Anna-Karina B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietrich-Ntoukas, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Geerling, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Viestenz, Arne UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhard, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600004
DOI:	10.1055/a-1353-6149
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	238
Number:	5
Page Range:	S. 591 - 598
Date:	2021
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NORMAL-RISK KERATOPLASTY; GRAFT-SURVIVAL; CORNEAL; COMPLICATIONS; PREVENTION Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60000