Universität zu Köln

Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Boll, Boris, Schellongowski, Peter, Valade, Sandrine, Metaxa, Victoria, Azoulay, Elie and von Bergwelt-Baildon, Michael (2022). Critical care management of chimeric antigen receptor T-cell therapy recipients. CA-Cancer J. Clin., 72 (1). S. 78 - 94. HOBOKEN: WILEY. ISSN 1542-4863

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Abstract

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic treatment concept that is changing the treatment approach to hematologic malignancies. The development of CAR T-cell therapy represents a prime example for the successful bench-to-bedside translation of advances in immunology and cellular therapy into clinical practice. The currently available CAR T-cell products have shown high response rates and long-term remissions in patients with relapsed/refractory acute lymphoblastic leukemia and relapsed/refractory lymphoma. However, CAR T-cell therapy can induce severe life-threatening toxicities such as cytokine release syndrome, neurotoxicity, or infection, which require rapid and aggressive medical treatment in the intensive care unit setting. In this review, the authors provide an overview of the state-of-the-art in the clinical management of severe life-threatening events in CAR T-cell recipients. Furthermore, key challenges that have to be overcome to maximize the safety of CAR T cells are discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shimabukuro-Vornhagen, Alexander UNSPECIFIED orcid.org/0000-0002-2351-7294 UNSPECIFIED Boll, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Schellongowski, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Valade, Sandrine UNSPECIFIED UNSPECIFIED UNSPECIFIED Metaxa, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Azoulay, Elie UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600344
DOI:	10.3322/caac.21702
Journal or Publication Title:	CA-Cancer J. Clin.
Volume:	72
Number:	1
Page Range:	S. 78 - 94
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1542-4863
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYTOKINE RELEASE SYNDROME; TERM-FOLLOW-UP; CD19; NEUROTOXICITY; TOXICITY; CYTOTOXICITY; TOCILIZUMAB; BIOMARKERS; CANCER; TRIAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60034