Jost, Stefanie T., Visser-Vandewalle, Veerle, Rizos, Alexandra, Loehrer, Philipp A., Silverdale, Monty, Evans, Julian, Samuel, Michael, Petry-Schmelzer, Jan Niklas, Sauerbier, Anna ORCID: 0000-0003-0966-5933, Gronostay, Alexandra, Barbe, Michael T. ORCID: 0000-0003-1149-8054, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Ashkan, Keyoumars, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Chaudhuri, K. Ray, Timmermann, Lars and Dafsari, Haidar S. (2021). Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease. npj Parkinsons Dis., 7 (1). BERLIN: NATURE RESEARCH. ISSN 2373-8057

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Abstract

To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable QoL responders/non-responders. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as QoL non-responders. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as 'difficulties experiencing pleasure' and 'problems sustaining concentration'. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jost, Stefanie T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehrer, Philipp A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverdale, MontyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petry-Schmelzer, Jan NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauerbier, AnnaUNSPECIFIEDorcid.org/0000-0003-0966-5933UNSPECIFIED
Gronostay, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDorcid.org/0000-0003-1149-8054UNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Ashkan, KeyoumarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Martinez-Martin, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudhuri, K. RayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-600395
DOI: 10.1038/s41531-021-00174-x
Journal or Publication Title: npj Parkinsons Dis.
Volume: 7
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2373-8057
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; NUCLEUS STIMULATION; OUTCOMES; NEUROSTIMULATION; SCORES; TRIAL; SCALEMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60039

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