Pruitt, Rory N., Locci, Federica, Wanke, Friederike ORCID: 0000-0001-6080-8800, Zhang, Lisha ORCID: 0000-0002-8203-2369, Saile, Svenja C., Joe, Anna, Karelina, Darya, Hua, Chenlei, Froehlich, Katja, Wan, Wei-Lin, Hu, Meijuan, Rao, Shaofei, Stolze, Sara C., Harzen, Anne ORCID: 0000-0001-7370-4939, Gust, Andrea A., Harter, Klaus, Joosten, Matthieu H. A. J., Thomma, Bart P. H. J., Zhou, Jian-Min, Dangl, Jeffery L., Weigel, Detlef ORCID: 0000-0002-2114-7963, Nakagami, Hirofumi ORCID: 0000-0003-2569-7062, Oecking, Claudia, El Kasmi, Farid ORCID: 0000-0002-4634-7689, Parker, Jane E. and Nuernberger, Thorsten (2021). The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature, 598 (7881). S. 495 - 518. BERLIN: NATURE PORTFOLIO. ISSN 1476-4687

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Abstract

Plants deploy cell-surface and intracellular leucine rich-repeat domain (LRR) immune receptors to detect pathogens(1). LRR receptor kinases and LRR receptor proteins at the plasma membrane recognize microorganism-derived molecules to elicit pattern-triggered immunity (PTI), whereas nucleotide-binding LRR proteins detect microbial effectors inside cells to confer effector-triggered immunity (ETI). Although PTI and ETI are initiated in different host cell compartments, they rely on the transcriptional activation of similar sets of genes(2), suggesting pathway convergence upstream of nuclear events. Here we report that PTI triggered by the Arabidopsis LRR receptor protein RLP23 requires signalling-competent dimers of the lipase-like proteins EDS1 and PAD4, and of ADR1 family helper nucleotide-binding LRRs, which are all components of ETI. The cell-surface LRR receptor kinase SOBIR1 links RLP23 with EDS1, PAD4 and ADR1 proteins, suggesting the formation of supramolecular complexes containing PTI receptors and transducers at the inner side of the plasma membrane. We detected similar evolutionary patterns in LRR receptor protein and nucleotide-binding LRR genes across Arabidopsis accessions; overall higher levels of variation in LRR receptor proteins than in LRR receptor kinases are consistent with distinct roles of these two receptor families in plant immunity. We propose that the EDS1-PAD4-ADR1 node is a convergence point for defence signalling cascades, activated by both surface-resident and intracellular LRR receptors, in conferring pathogen immunity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pruitt, Rory N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Locci, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wanke, FriederikeUNSPECIFIEDorcid.org/0000-0001-6080-8800UNSPECIFIED
Zhang, LishaUNSPECIFIEDorcid.org/0000-0002-8203-2369UNSPECIFIED
Saile, Svenja C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joe, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karelina, DaryaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hua, ChenleiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froehlich, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wan, Wei-LinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hu, MeijuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rao, ShaofeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stolze, Sara C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harzen, AnneUNSPECIFIEDorcid.org/0000-0001-7370-4939UNSPECIFIED
Gust, Andrea A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harter, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joosten, Matthieu H. A. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomma, Bart P. H. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, Jian-MinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dangl, Jeffery L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, DetlefUNSPECIFIEDorcid.org/0000-0002-2114-7963UNSPECIFIED
Nakagami, HirofumiUNSPECIFIEDorcid.org/0000-0003-2569-7062UNSPECIFIED
Oecking, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Kasmi, FaridUNSPECIFIEDorcid.org/0000-0002-4634-7689UNSPECIFIED
Parker, Jane E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberger, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-601001
DOI: 10.1038/s41586-021-03829-0
Journal or Publication Title: Nature
Volume: 598
Number: 7881
Page Range: S. 495 - 518
Date: 2021
Publisher: NATURE PORTFOLIO
Place of Publication: BERLIN
ISSN: 1476-4687
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RECEPTOR-LIKE PROTEINS; PLANT; VECTORS; KINASE; COMPLEX; DOMAIN; GENES; EDS1; PAD4Multiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60100

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