Universität zu Köln

Park, Sang-Don, Orban, Mathias, Karam, Nicole ORCID: 0000-0002-3861-6914, Lubos, Edith, Kalbacher, Daniel, Braun, Daniel, Stolz, Lukas, Neuss, Michael, Butter, Christian, Praz, Fabien ORCID: 0000-0001-5416-165X, Kassar, Mohammad, Petrescu, Aniela, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias ORCID: 0000-0002-8175-276X, Lurz, Philipp, Thiele, Holger, Baldus, Stephan, von Bardeleben, Stephan, Blankenberg, Stefan, Massberg, Steffen, Windecker, Stephan and Hausleiter, Jorg (2021). Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. JACC-Cardiovasc. Interv., 14 (8). S. 819 - 828. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

OBJECTIVES The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR). BACKGROUND Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown. METHODS The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation). RESULTS A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade <= 2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up. CONCLUSIONS Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up. (C) 2021 by the American College of Cardiology Foundation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Park, Sang-Don UNSPECIFIED UNSPECIFIED UNSPECIFIED Orban, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Karam, Nicole UNSPECIFIED orcid.org/0000-0002-3861-6914 UNSPECIFIED Lubos, Edith UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbacher, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuss, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Butter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Praz, Fabien UNSPECIFIED orcid.org/0000-0001-5416-165X UNSPECIFIED Kassar, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrescu, Aniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Iliadis, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Unterhuber, Matthias UNSPECIFIED orcid.org/0000-0002-8175-276X UNSPECIFIED Lurz, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bardeleben, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankenberg, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Massberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Windecker, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausleiter, Jorg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601707
DOI:	10.1016/j.jcin.2020.12.042
Journal or Publication Title:	JACC-Cardiovasc. Interv.
Volume:	14
Number:	8
Page Range:	S. 819 - 828
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-7605
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVAL; NATIVE VALVULAR REGURGITATION; EUROPEAN ASSOCIATION; HEART-FAILURE; VALVE REPAIR; FOLLOW-UP; GENDER; RECOMMENDATIONS; IMPACT Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60170