Universität zu Köln

Grubmueller, Bernhard, Jahrreiss, Victoria, Bronimann, Stephan, Quhal, Fahad ORCID: 0000-0002-8163-6953, Mori, Keiichiro, Heidenreich, Axel, Briganti, Alberto, Tilki, Derya and Shariat, Shahrokh F. (2021). Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response. Curr. Oncol., 28 (4). S. 2881 - 2893. BASEL: MDPI. ISSN 1718-7729

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Abstract

A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January 1980 and April 2020. Overall, 23 English language articles including a total number of 2323 patients were selected according to PRISMA criteria. The overall median follow-up was 37.5 months (IQR 35.5-52.5). Biochemical-recurrence (BCR)-free probability ranged from 34% to 83% at five years, respectively, and from 31% to 37% at 10 years. Cancer specific survival (CSS) and overall survival (OS) ranged from 88.7% to 98% and 64% to 95% at five years and from 72% to 83% and 65% to 72% at 10 years, respectively. Positive surgical margins ranged from 14% to 45.8% and pathologic organ-confined disease was reported from 20% to 57%. The rate of pathologic > T2-disease ranged from 37% to 80% and pN1 disease differed between 0% to 78.4%. Pre-SRP PSA, pre-SRP Gleason Score (GS), pathologic stage after SRP, and pathologic lymph node involvement seemed to be the strongest prognostic factors for good outcomes. SRP provides accurate histopathological and functional outcomes, as well as durable cancer control. Careful patient counseling in a shared decision-making process is recommended.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grubmueller, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahrreiss, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Bronimann, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Quhal, Fahad UNSPECIFIED orcid.org/0000-0002-8163-6953 UNSPECIFIED Mori, Keiichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Briganti, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Tilki, Derya UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601742
DOI:	10.3390/curroncol28040252
Journal or Publication Title:	Curr. Oncol.
Volume:	28
Number:	4
Page Range:	S. 2881 - 2893
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1718-7729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN-DEPRIVATION THERAPY; RADIATION-THERAPY; RADIOTHERAPY; COMPLICATIONS; PATTERNS; FAILURE; SURGERY; IMPACT Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60174