Universität zu Köln

Bestfater, Christian, Vehreschild, Maria J. G. T., Stallmach, Andreas, Tueffers, Kester, Erhardt, Andreas, Frank, Thorsten, Glueck, Thomas, Goeser, Felix ORCID: 0000-0003-3190-9981, Sellge, Gernot, Solbach, Philipp, Eisenlohr, Herbert and Storr, Martin (2021). Clinical effectiveness of bidirectional fecal microbiota transfer in the treatment of recurrent Clostridioides difficile infections. Dig. Liver Dis., 53 (6). S. 706 - 712. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-3562

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Abstract

Background: Fecal microbiota transfer (FMT) has become a standard of care in the prevention of multiple recurrent Clostridioides difficile (rCDI) infection. Aim: While primary cure rates range from 70-80% following a single treatment using monodirectional approaches, cure rates of combination treatment remain largely unknown. Methods: In a retrospective case-control study, outcomes following simultaneous bidirectional FMT (bFMT) with combined endoscopic application into the upper and lower gastrointestinal tract, compared to standard routes of application (endoscopy via upper or lower gastrointestinal tract and oral capsules; abbreviated UGIT, LGIT and CAP) on day 30 and 90 after FMT were assessed. Statistical matching partners were identified using number of recurrences ( < 3; >= 3), age and gender. Results: Primary cure rates at D30 and D90 for bFMT were 100% ( p = .001). The matched control groups showed cure rates of 81.3% for LGIT ( p = .010), 62.5% for UGIT ( p = .0 0 0) and 78.1% for CAP ( p = .005) on D30 and 81.3% for LGIT ( p = .010), 59.4% for UGIT ( p = .0 0 0) and 71.9% for CAP ( p = .001) on D90. Conclusion: In our analysis, bFMT on the same day significantly increased primary cure rate at D30 and D90. These data require prospective confirmation but suggest that route of application may play a signif-icant role in optimizing patient outcomes. ClinicalTrials.gov no: NCT026 8106 8 (c) 2021 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bestfater, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stallmach, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Tueffers, Kester UNSPECIFIED UNSPECIFIED UNSPECIFIED Erhardt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Glueck, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeser, Felix UNSPECIFIED orcid.org/0000-0003-3190-9981 UNSPECIFIED Sellge, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED Solbach, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenlohr, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Storr, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601812
DOI:	10.1016/j.dld.2021.02.022
Journal or Publication Title:	Dig. Liver Dis.
Volume:	53
Number:	6
Page Range:	S. 706 - 712
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-3562
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSPLANTATION; EFFICACY Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60181