Universität zu Köln

Sauerbier, Anna, Loehrer, Philipp, Jost, Stefanie T., Heil, Shania, Petry-Schmelzer, Jan N., Herberg, Johanna, Bachon, Pia, Aloui, Salima, Gronostay, Alexandra, Klingelhoefer, Lisa, Baldermann, J. Carlos, Huys, Daniel ORCID: 0000-0002-9124-4128, Nimsky, Christopher ORCID: 0000-0002-8216-9410, Barbe, Michael T. ORCID: 0000-0003-1149-8054, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Martinez-Martin, Pablo, Ray Chaudhuri, K., Visser-Vandewalle, Veerle, Timmermann, Lars, Weintraub, Daniel and Dafsari, Haidar S. (2021). Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease. J. Neurol. Neurosurg. Psychiatry, 92 (12). S. 1313 - 1319. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

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Abstract

Background The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson's disease (PD) are understudied. Objective To investigate clinical predictors of STN-DBS effects on ICB. Methods In this prospective, open-label, multicentre study in patients with PD undergoing bilateral STN-DBS, we assessed patients preoperatively and at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), PD Questionnaire-8, Non-Motor Symptom Scale (NMSS), Unified PD Rating Scale in addition to levodopa-equivalent daily dose total (LEDD-total) and dopamine agonists (LEDD-DA). Changes at follow-up were analysed with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We explored predictors of QUIP-RS changes using correlations and linear regressions. Finally, we dichotomised patients into 'QUIP-RS improvement or worsening' and analysed between-group differences. Results We included 55 patients aged 61.7 years +/- 8.4 with 9.8 years +/- 4.6 PD duration. QUIP-RS cut-offs and psychiatric assessments identified patients with preoperative ICB. In patients with ICB, QUIP-RS improved significantly. However, we observed considerable interindividual variability of clinically relevant QUIP-RS outcomes as 27.3% experienced worsening and 29.1% an improvement. In post hoc analyses, higher baseline QUIP-RS and lower baseline LEDD-DA were associated with greater QUIP-RS improvements. Additionally, the 'QUIP-RS worsening' group had more severe baseline impairment in the NMSS attention/memory domain. Conclusions Our results show favourable ICB outcomes in patients with higher preoperative ICB severity and lower preoperative DA doses, and worse outcomes in patients with more severe baseline attention/memory deficits. These findings emphasise the need for comprehensive non-motor and motor symptoms assessments in patients undergoing STN-DBS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sauerbier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehrer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Jost, Stefanie T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heil, Shania UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herberg, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachon, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Aloui, Salima UNSPECIFIED UNSPECIFIED UNSPECIFIED Gronostay, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingelhoefer, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, J. Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Nimsky, Christopher UNSPECIFIED orcid.org/0000-0002-8216-9410 UNSPECIFIED Barbe, Michael T. UNSPECIFIED orcid.org/0000-0003-1149-8054 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Ray Chaudhuri, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Weintraub, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602038
DOI:	10.1136/jnnp-2021-326131
Journal or Publication Title:	J. Neurol. Neurosurg. Psychiatry
Volume:	92
Number:	12
Page Range:	S. 1313 - 1319
Date:	2021
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-330X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; QUALITY-OF-LIFE; NONMOTOR SYMPTOMS; RATING-SCALE; DISORDERS; DOPAMINE; NUCLEUS; QUESTIONNAIRE; VALIDATION; NEUROSTIMULATION Multiple languages Clinical Neurology; Psychiatry; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60203