Universität zu Köln

Quarta, Carmelo, Claret, Marc ORCID: 0000-0001-7766-9296, Zeltser, Lori M., Williams, Kevin W., Yeo, Giles S. H., Tschoep, Matthias H., Diano, Sabrina, Bruening, Jens C. and Cota, Daniela ORCID: 0000-0002-6909-2156 (2021). POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat. Metab., 3 (3). S. 299 - 309. BERLIN: NATURE PORTFOLIO. ISSN 2522-5812

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Abstract

Quarta et al. discuss POMC neuronal heterogeneity and how specific subpopulations of POMC neurons can have diverse effects on appetite, whole-body metabolic physiology and the development of obesity. Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body's energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism. However, although AgRP neurons' functions are comparatively well understood, a unifying theory of how POMC neuronal cells operate has remained elusive, probably due to their high level of heterogeneity, which suggests that their physiological roles might be more complex than initially thought. In this Perspective, we propose a conceptual framework that integrates POMC neuronal heterogeneity with appetite regulation, whole-body metabolic physiology and the development of obesity. We highlight emerging evidence indicating that POMC neurons respond to distinct combinations of interoceptive signals and food-related cues to fine-tune divergent metabolic pathways and behaviours necessary for survival. The new framework we propose reflects the high degree of developmental plasticity of this neuronal population and may enable progress towards understanding of both the aetiology and treatment of metabolic disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quarta, Carmelo UNSPECIFIED UNSPECIFIED UNSPECIFIED Claret, Marc UNSPECIFIED orcid.org/0000-0001-7766-9296 UNSPECIFIED Zeltser, Lori M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Kevin W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yeo, Giles S. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tschoep, Matthias H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diano, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cota, Daniela UNSPECIFIED orcid.org/0000-0002-6909-2156 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602826
DOI:	10.1038/s42255-021-00345-3
Journal or Publication Title:	Nat. Metab.
Volume:	3
Number:	3
Page Range:	S. 299 - 309
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2522-5812
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60282