Song, Mengmeng, Beyer, Leonie, Kaiser, Lena, Barthel, Henryk, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Marek, Ken, Nitschmann, Alexander, Scheifele, Maximilian, Palleis, Carla, Respondek, Gesine, Kern, Maike, Biechele, Gloria, Hammes, Jochen, Bischof, Gerard, Barbe, Michael, Onur, Ozgur, Jessen, Frank, Saur, Dorothee ORCID: 0000-0002-1808-0913, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael ORCID: 0000-0002-2683-9432, Schildan, Andreas, Patt, Marianne, Neumaier, Bernd, Barret, Olivier, Madonia, Jennifer, Russell, David S., Stephens, Andrew W., Mueller, Andre ORCID: 0000-0001-7271-9303, Roeber, Sigrun, Herms, Jochen, Botzel, Kai, Danek, Adrian, Levin, Johannes ORCID: 0000-0001-5092-4306, Classen, Joseph, Hoglinger, Gunter U., Bartenstein, Peter, Villemagne, Victor, Drzezga, Alexander ORCID: 0000-0001-6018-716X, Seibyl, John, Sabri, Osama, Boening, Guido, Ziegler, Sibylle and Brendel, Matthias (2021). Binding characteristics of [F-18]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET. J. Cereb. Blood Flow Metab., 41 (11). S. 2957 - 2973. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1559-7016

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Abstract

The novel tau-PET tracer [F-18]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [F-18]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [F-18]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [F-18]PI-2620-positive clusters (DVR >= 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1(SRTM): 0.92 +/- 0.21 vs. 0.83 +/- 0.10, p = 0.0007), higher efflux (k2(SRTM): 0.17/min +/- 0.21/min vs. 0.06/min +/- 0.07/min, p < 0.0001), lower DVR (1.1 +/- 0.1 vs. 1.4 +/- 0.2, p < 0.0001), lower SUVR30-60 (1.3 +/- 0.2 vs. 1.8 +/- 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope(9-60): 0.006/min +/- 0.007/min vs. 0.016/min +/- 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [F-18]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Song, MengmengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyer, LeonieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barthel, HenrykUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDorcid.org/0000-0002-6951-2325UNSPECIFIED
Marek, KenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nitschmann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheifele, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palleis, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Respondek, GesineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biechele, GloriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammes, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischof, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onur, OzgurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saur, DorotheeUNSPECIFIEDorcid.org/0000-0002-1808-0913UNSPECIFIED
Schroeter, Matthias L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rumpf, Jost-JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rullmann, MichaelUNSPECIFIEDorcid.org/0000-0002-2683-9432UNSPECIFIED
Schildan, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patt, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barret, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madonia, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, David S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephens, Andrew W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, AndreUNSPECIFIEDorcid.org/0000-0001-7271-9303UNSPECIFIED
Roeber, SigrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herms, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Botzel, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danek, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levin, JohannesUNSPECIFIEDorcid.org/0000-0001-5092-4306UNSPECIFIED
Classen, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoglinger, Gunter U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartenstein, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDorcid.org/0000-0001-6018-716XUNSPECIFIED
Seibyl, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabri, OsamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boening, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, SibylleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brendel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603863
DOI: 10.1177/0271678X211018904
Journal or Publication Title: J. Cereb. Blood Flow Metab.
Volume: 41
Number: 11
Page Range: S. 2957 - 2973
Date: 2021
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1559-7016
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON-EMISSION-TOMOGRAPHY; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; TRACER F-18-AV-1451; PATHOLOGY; DIAGNOSIS; CRITERIA; BRAIN; T807Multiple languages
Endocrinology & Metabolism; Hematology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60386

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