Universität zu Köln

Szejko, Natalia, Worbe, Yulia ORCID: 0000-0001-5903-9370, Hartmann, Andreas ORCID: 0000-0002-0335-984X, Visser-Vandewalle, Veerle, Ackermans, Linda, Ganos, Christos, Porta, Mauro, Leentjens, Albert F. G., Mehrkens, Jan-Hinnerk, Huys, Daniel ORCID: 0000-0002-9124-4128, Baldermann, Juan Carlos, Kuhn, Jens, Karachi, Carine, Delorme, Cecile, Foltynie, Thomas, Cavanna, Andrea E., Cath, Danielle and Mueller-Vahl, Kirsten (2022). European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part IV: deep brain stimulation. Eur. Child Adolesc. Psych., 31 (3). S. 443 - 462. NEW YORK: SPRINGER. ISSN 1435-165X

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Abstract

In 2011 the European Society for the Study of Tourette Syndrome (ESSTS) published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) with part IV on deep brain stimulation (DBS). Here, we present a revised version of these guidelines with updated recommendations based on the current literature covering the last decade as well as a survey among ESSTS experts. Currently, data from the International Tourette DBS Registry and Database, two meta-analyses, and eight randomized controlled trials (RCTs) are available. Interpretation of outcomes is limited by small sample sizes and short follow-up periods. Compared to open uncontrolled case studies, RCTs report less favorable outcomes with conflicting results. This could be related to several different aspects including methodological issues, but also substantial placebo effects. These guidelines, therefore, not only present currently available data from open and controlled studies, but also include expert knowledge. Although the overall database has increased in size since 2011, definite conclusions regarding the efficacy and tolerability of DBS in TS are still open to debate. Therefore, we continue to consider DBS for TS as an experimental treatment that should be used only in carefully selected, severely affected and otherwise treatment-resistant patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Szejko, Natalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Worbe, Yulia UNSPECIFIED orcid.org/0000-0001-5903-9370 UNSPECIFIED Hartmann, Andreas UNSPECIFIED orcid.org/0000-0002-0335-984X UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Ackermans, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganos, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Porta, Mauro UNSPECIFIED UNSPECIFIED UNSPECIFIED Leentjens, Albert F. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehrkens, Jan-Hinnerk UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Karachi, Carine UNSPECIFIED UNSPECIFIED UNSPECIFIED Delorme, Cecile UNSPECIFIED UNSPECIFIED UNSPECIFIED Foltynie, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavanna, Andrea E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cath, Danielle UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Vahl, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603986
DOI:	10.1007/s00787-021-01881-9
Journal or Publication Title:	Eur. Child Adolesc. Psych.
Volume:	31
Number:	3
Page Range:	S. 443 - 462
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-165X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOBUS-PALLIDUS INTERNUS; QUALITY-OF-LIFE; TERM-FOLLOW-UP; LONG-TERM; DOUBLE-BLIND; THALAMIC-STIMULATION; PATIENT SELECTION; NUCLEUS-ACCUMBENS; ASSESSMENT RECOMMENDATIONS; TRIAL Multiple languages Psychology, Developmental; Pediatrics; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60398