Li, Shumei, Daamen, Marcel ORCID: 0000-0002-3017-3901, Scheef, Lukas, Gaertner, Florian C., Buchert, Ralph, Buchmann, Martina, Buerger, Katharina, Catak, Cihan, Dobisch, Laura, Drzezga, Alexander ORCID: 0000-0001-6018-716X, Ertl-Wagner, Birgit ORCID: 0000-0002-7896-7049, Essler, Markus, Fliessbach, Klaus, Haynes, John Dylan, Incesoy, Enise Irem, Kilimann, Ingo, Krause, Bernd J., Lange, Catharina ORCID: 0000-0002-6745-8441, Laske, Christoph, Priller, Josef ORCID: 0000-0001-7596-0979, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Reimold, Matthias, Rominger, Axel, Roy, Nina, Scheffler, Klaus, Maurer, Angelika ORCID: 0000-0002-6067-3253, Schneider, Anja ORCID: 0000-0001-9540-8700, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Tscheuschler, Maike, Wagner, Michael ORCID: 0000-0003-2589-6440, Wolfsgruber, Steffen, Duzel, Emrah ORCID: 0000-0002-0139-5388, Jessen, Frank, Peters, Oliver ORCID: 0000-0003-0568-2998 and Boecker, Henning ORCID: 0000-0003-2346-0598 (2021). Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. J. Alzheimers Dis., 79 (2). S. 493 - 510. AMSTERDAM: IOS PRESS. ISSN 1875-8908

Full text not available from this repository.

Abstract

Background: Amyloid-beta accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework. Objective: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus. Methods: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDA beta+) and amyloidnegative SCD (SCDA beta-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVRFBB). Results: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDA beta+ patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDA beta+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDA beta+) and precuneus SUVRFBB (both groups). Conclusion: While partial confounding influences due to a higher APOE epsilon 4 carrier ratio among SCDA beta+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-beta load, highlighting incipient pathology in stage 2 of the AD continuum.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Li, ShumeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daamen, MarcelUNSPECIFIEDorcid.org/0000-0002-3017-3901UNSPECIFIED
Scheef, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaertner, Florian C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchert, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchmann, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Catak, CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDorcid.org/0000-0001-6018-716XUNSPECIFIED
Ertl-Wagner, BirgitUNSPECIFIEDorcid.org/0000-0002-7896-7049UNSPECIFIED
Essler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, John DylanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Incesoy, Enise IremUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krause, Bernd J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, CatharinaUNSPECIFIEDorcid.org/0000-0002-6745-8441UNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDorcid.org/0000-0001-7596-0979UNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Reimold, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rominger, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maurer, AngelikaUNSPECIFIEDorcid.org/0000-0002-6067-3253UNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tscheuschler, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzel, EmrahUNSPECIFIEDorcid.org/0000-0002-0139-5388UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDorcid.org/0000-0003-0568-2998UNSPECIFIED
Boecker, HenningUNSPECIFIEDorcid.org/0000-0003-2346-0598UNSPECIFIED
URN: urn:nbn:de:hbz:38-604393
DOI: 10.3233/JAD-200472
Journal or Publication Title: J. Alzheimers Dis.
Volume: 79
Number: 2
Page Range: S. 493 - 510
Date: 2021
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
F-18-FLORBETABEN PET SCANS; NORMAL OLDER-ADULTS; FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; BRAIN ACTIVITY; DEFAULT-MODE; CLINICAL-TRIALS; CORTICAL HUBS; BETA; NETWORKMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60439

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item