Universität zu Köln

Rajwa, Pawel, Schuettfort, Victor M., Quhal, Fahad, Mori, Keiichiro, Katayama, Satoshi, Laukhtina, Ekaterina, Pradere, Benjamin, Motlagh, Reza Sari, Mostafaei, Hadi ORCID: 0000-0001-5596-1771, Grossmann, Nico C., Aulitzky, Andreas, Paradysz, Andrzej ORCID: 0000-0003-1742-8372, Karakiewicz, Pierre I., Fajkovic, Harun, Zimmermann, Kristin, Heidenreich, Axel, Gontero, Paolo and Shariat, Shahrokh F. (2021). Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy. World J. Urol., 39 (10). S. 3771 - 3780. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Purpose To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP). Materials and methods This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils x platelets/lymphocytes) and the cohort was stratified using optimal cut-off. Uni- and multivariable logistic and Cox regression analyses were performed to evaluate the predictive and prognostic value of SII as a preoperative biomarker. Results A total of 81 patients had high preoperative SII (>= 730). On multivariable logistic regression modeling, high SII was predictive for lymph node metastases (OR 3.32, 95% CI 1.45-7.90, p = 0.005), and non-organ confined disease (OR 2.55, 95% CI 1.33-4.97, p = 0.005). In preoperative regression analysis, high preoperative SII was an independent prognostic factor for cancer-specific survival (CSS; HR 10.7, 95% CI 1.12-103, p = 0.039) and overall survival (OS; HR 8.57, 95% CI 2.70-27.2, p < 0.001). Similarly, in postoperative multivariable models, SII was associated with worse CSS (HR 22.11, 95% CI 1.23-398.12, p = 0.036) and OS (HR 5.98, 95% CI 1.67-21.44, p = 0.006). Notably, the addition of SII to preoperative reference models improved the C-index for the prognosis of CSS (89.5 vs. 80.5) and OS (85.1 vs 77.1). Conclusions In radio-recurrent PCa patients, high SII was associated with adverse pathological features at SRP and survival after SRP. Preoperative SII could help identify patients who might benefit from novel imaging modalities, multimodal therapy or a closer posttreatment surveillance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rajwa, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuettfort, Victor M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quhal, Fahad UNSPECIFIED UNSPECIFIED UNSPECIFIED Mori, Keiichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Katayama, Satoshi UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukhtina, Ekaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pradere, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Motlagh, Reza Sari UNSPECIFIED UNSPECIFIED UNSPECIFIED Mostafaei, Hadi UNSPECIFIED orcid.org/0000-0001-5596-1771 UNSPECIFIED Grossmann, Nico C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aulitzky, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Paradysz, Andrzej UNSPECIFIED orcid.org/0000-0003-1742-8372 UNSPECIFIED Karakiewicz, Pierre I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fajkovic, Harun UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmermann, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gontero, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-604652
DOI:	10.1007/s00345-021-03715-4
Journal or Publication Title:	World J. Urol.
Volume:	39
Number:	10
Page Range:	S. 3771 - 3780
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-8726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; RADIOTHERAPY; PREDICTS; RADIATION; THERAPY Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60465